A spatially propagating biochemical reaction

Xiaoli Liao*, Rafe T. Petty, Milan Mrksich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Surfing with the kinase: A soluble kinase phosphorylates an immobilized peptide substrate most rapidly at the boundary between product and substrate, and gives rise to a "wave" of propagating product. Such systems offer an approach to engineering reactions to give spatio-temporal control over progression of reactions.

Original languageEnglish (US)
Pages (from-to)706-708
Number of pages3
JournalAngewandte Chemie - International Edition
Volume50
Issue number3
DOIs
StatePublished - Jan 17 2011

Keywords

  • adaptor domains
  • autocatalysis
  • monolayers
  • phosphorylation
  • propagation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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