A splenic requirement for the generation of suppressor T cells

M. Sy, S. D. Miller, H. B. Kowach, H. N. Claman

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Tolerance to contact sensitization with DNFB may be induced by DNBSO3. This specific unresponsiveness may occur via one or both of two mechanisms - production of suppressor T cells or clone inhibition. We investigated the role of the spleen in this unresponsiveness. Splenectomized mice may be tolerized by i.v. injection of DNBSO3, but they are incapable of serving as donors of lymph node cells for transfer of tolerance to normal recipients. Kinetic studies indicated that the spleen must be present at least three days after tolerization in order to permit development of a significant number of suppressor cells in the peripheral lymph nodes. We interpret these results to indicate that clone inhibition does not require the spleen, the generation of suppressor T cells is dependent on the presence of the spleen, and it is likely that tolerogens in this system induce suppressor cells in the spleen and some of these cells or their products leave the spleen to reach the peripheral lymph nodes.

Original languageEnglish (US)
Pages (from-to)2095-2099
Number of pages5
JournalJournal of Immunology
Issue number6
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • Immunology


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