A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling

Jiyoun Lee; Mark J. Zylka; David J. Anderson; Joanna E. Burdette; Teresa K. Woodruff; Thomas J. Meade

doi:10.1021/ja051294x

A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling

Jiyoun Lee, Mark J. Zylka, David J. Anderson, Joanna E. Burdette, Teresa K. Woodruff, Thomas J. Meade^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

We have synthesized the first steroid hormone-MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.

Original language	English (US)
Pages (from-to)	13164-13166
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	127
Issue number	38
DOIs	https://doi.org/10.1021/ja051294x
State	Published - Sep 28 2005

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/ja051294x

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abstract = "We have synthesized the first steroid hormone-MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.",

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AU - Woodruff, Teresa K.

AU - Meade, Thomas J.

PY - 2005/9/28

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A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling

Abstract

ASJC Scopus subject areas

UN SDGs

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