A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

Nazar Mashtalir, Hiroshi Suzuki, Daniel P. Farrell, Akshay Sankar, Jie Luo, Martin Filipovski, Andrew R. D'Avino, Roodolph St. Pierre, Alfredo M. Valencia, Takashi Onikubo, Robert G. Roeder, Yan Han, Yuan He, Jeffrey A. Ranish, Frank DiMaio*, Thomas Walz, Cigall Kadoch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Structural analysis of an endogenous human SWI/SNF complex shows how it engages with nucleosomes and provides insight into how cancer-associated mutations affect the remodeler's function.

Original languageEnglish (US)
Pages (from-to)802-817.e24
JournalCell
Volume183
Issue number3
DOIs
StatePublished - Oct 29 2020

Keywords

  • ATP-dependent chromatin remodeling
  • BAF complex
  • cancer
  • cross-linking mass spectrometry
  • cryoelectron microscopy
  • homology modeling
  • mammalian SWI/SNF complexes
  • mutations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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