A study of paternal age and sex ratio in sperm chromosome complements

R. Martin*, A. W. Rademaker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


There is conflicting evidence as to whether the secondary sex ratio in humans decreases with paternal age. Such an age effect could be caused by an altered frequency in the production of X-chromosome and Y-chromosome-bearing sperm as a man ages. To study this possibility we analysed 9,225 sperm karyotypes from 143 men aged 21-55 years. Human pronuclear sperm chromosome complements were obtained after fusion with golden hamster oocytes. The percentage of X- and Y-chromosome complements was not significantly related to donor age.

Original languageEnglish (US)
Pages (from-to)333-336
Number of pages4
JournalHuman Heredity
Issue number6
StatePublished - Jan 1 1992


  • Paternal age
  • Sex ratio
  • Sperm chromosomes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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