A study of Vitamin K status in children on prolonged antibiotic therapy

Rukhmi V. Bhat*, C. T. Deshmukh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Vitamin K deficiency is known to cause coagulopathy and bleeding in patients on prolonged antibiotic therapy. This study was conducted to evaluate the status of vitamin K deficiency in hospitalized children on prolonged antibiotic therapy and its role in reversing the coagulopathy. A prospective non-randomized study was conducted on children on antibiotic therapy at a tertiary care hospital. Children in the 1 month-1 year age group developed significant coagulopathy as compared to other age groups. Coagulation abnormalities were also seen to be more in children with greater grades of malnutrition, a more prolonged course of antibiotics and in children who were critically ill in intensive care. Hypoprothrombinemia previously reported to be due to B-lactam antibiotics containing the N-Methyl Thio Tetrazole (NMTT) group also resulted from antibiotics without this side chain. Inhibition of intestinal microorganisms by antibiotics was thought to be a likely explanation of this phenomenon. We suggest Vitamin K prophylaxis in severely ill patients, on extended periods of antibiotics and inadequate diet to prevent morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalIndian Pediatrics
Issue number1
StatePublished - Jan 1 2003


  • Antibiotic therapy
  • Vitamin K

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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