Abstract
POU2AF2 is a co-activator of POU2F3 in normal and neoplastic tuft cells, such as small cell lung cancer. Here, the authors report that POU2AF2 dictates opposing transcriptional regulation at distal enhance elements.
| Original language | English (US) |
|---|---|
| Article number | 2067 |
| Journal | Nature communications |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 2024 |
Funding
We are grateful to all the current and past Wang Lab members for their support. We want to thank Hiam Abdala-Valencia for CRISPR screen library sequencing. We thank Aidan Balagtas, Angela Beatrice Lichauco, and Rima Tulaiha for the experimental material prep. The lentiCRISPR v2 vector was a gift from Feng Zhang. The lentiCRISPR v2-Blast vector was a gift from Mohan Babu. L.W. is supported by NIH grant R35GM146979, the Research Scholar Grant (RSG-22-039-01-DMC) from the American Cancer Society, and the Idea Development Award (HT94252310360) from USAMRAA. F.Y. is supported by NIH grants R35GM124820, R01HG009906, and R01HG011207. We are grateful to all the current and past Wang Lab members for their support. We want to thank Hiam Abdala-Valencia for CRISPR screen library sequencing. We thank Aidan Balagtas, Angela Beatrice Lichauco, and Rima Tulaiha for the experimental material prep. The lentiCRISPR v2 vector was a gift from Feng Zhang. The lentiCRISPR v2-Blast vector was a gift from Mohan Babu. L.W. is supported by NIH grant R35GM146979, the Research Scholar Grant (RSG-22-039-01-DMC) from the American Cancer Society, and the Idea Development Award (HT94252310360) from USAMRAA. F.Y. is supported by NIH grants R35GM124820, R01HG009906, and R01HG011207.
ASJC Scopus subject areas
- General Chemistry
- General Biochemistry, Genetics and Molecular Biology
- General Physics and Astronomy
