A symbiotic concept of autoimmunity and tumour immunity: Lessons from vitiligo

Pranab K. Das*, René M.J.G.J. Van Den Wijngaard, Anna Wankowicz-Kalinska, I. Caroline Le Poole

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.

Original languageEnglish (US)
Pages (from-to)130-136
Number of pages7
JournalTrends in Immunology
Volume22
Issue number3
DOIs
StatePublished - Aug 4 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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