TY - JOUR
T1 - A symbiotic concept of autoimmunity and tumour immunity
T2 - Lessons from vitiligo
AU - Das, Pranab K.
AU - Van Den Wijngaard, René M.J.G.J.
AU - Wankowicz-Kalinska, Anna
AU - Le Poole, I. Caroline
PY - 2001/8/4
Y1 - 2001/8/4
N2 - Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.
AB - Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.
UR - http://www.scopus.com/inward/record.url?scp=0034913686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034913686&partnerID=8YFLogxK
U2 - 10.1016/S1471-4906(00)01844-5
DO - 10.1016/S1471-4906(00)01844-5
M3 - Review article
C2 - 11286727
AN - SCOPUS:0034913686
SN - 1471-4906
VL - 22
SP - 130
EP - 136
JO - Trends in Immunology
JF - Trends in Immunology
IS - 3
ER -