A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Martina Sanderson-Smith; David M P De Oliveira; Julien Guglielmini; David J. McMillan; Therese Vu; Jessica K. Holien; Anna Henningham; Andrew C. Steer; Debra E. Bessen; James B. Dale; Nigel Curtis; Bernard W. Beall; Mark J. Walker; Michael W. Parker; Jonathan R. Carapetis; Laurence Van Melderen; Kadaba S. Sriprakash; Pierre R. Smeesters; Michael Batzloff; Rebecca Towers; Herman Goossens; Surhbi Malhotra-Kumar; Luiza Guilherme; Rosangela Torres; Donald Low; Allison McGeer; Paula Krizova; Sawsan El Tayeb; Joe Kado; Mark Van Der Linden; Guliz Erdem; Alon Moses; Ran Nir-Paz; Tadayoshi Ikebe; Haruo Watanabe; Samba Sow; Boubou Tamboura; Bard Kittang; José Melo-Cristino; Mario Ramirez; Monica Straut; Alexander Suvorov; Artem Totolian; Mark Engel; Bongani Mayosi; Andrew Whitelaw; Jessica Darenberg; Birgitta Henriques Normark; Chuan Chiang Ni; Jiunn Jong Wu; Aruni De Zoysa; Androulla Efstratiou; Stanford Shulman; Robert Tanz

doi:10.1093/infdis/jiu260

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Martina Sanderson-Smith, David M P De Oliveira, Julien Guglielmini, David J. McMillan, Therese Vu, Jessica K. Holien, Anna Henningham, Andrew C. Steer, Debra E. Bessen, James B. Dale, Nigel Curtis, Bernard W. Beall, Mark J. Walker, Michael W. Parker, Jonathan R. Carapetis, Laurence Van Melderen, Kadaba S. Sriprakash, Pierre R. Smeesters^*, Michael Batzloff, Rebecca TowersHerman Goossens, Surhbi Malhotra-Kumar, Luiza Guilherme, Rosangela Torres, Donald Low, Allison McGeer, Paula Krizova, Sawsan El Tayeb, Joe Kado, Mark Van Der Linden, Guliz Erdem, Alon Moses, Ran Nir-Paz, Tadayoshi Ikebe, Haruo Watanabe, Samba Sow, Boubou Tamboura, Bard Kittang, José Melo-Cristino, Mario Ramirez, Monica Straut, Alexander Suvorov, Artem Totolian, Mark Engel, Bongani Mayosi, Andrew Whitelaw, Jessica Darenberg, Birgitta Henriques Normark, Chuan Chiang Ni, Jiunn Jong Wu, Aruni De Zoysa, Androulla Efstratiou, Stanford Shulman, Robert Tanz

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

248 Scopus citations

Abstract

Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.

Original language	English (US)
Pages (from-to)	1325-1338
Number of pages	14
Journal	Journal of Infectious Diseases
Volume	210
Issue number	8
DOIs	https://doi.org/10.1093/infdis/jiu260
State	Published - Jan 1 2014

Keywords

Epidemiology
Fibrinogen
IgA
IgG
M protein
Molecular typing
Plasminogen
Streptococcus pyogenes
Vaccine

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiu260

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Sanderson-Smith, M., De Oliveira, D. M. P., Guglielmini, J., McMillan, D. J., Vu, T., Holien, J. K., Henningham, A., Steer, A. C., Bessen, D. E., Dale, J. B., Curtis, N., Beall, B. W., Walker, M. J., Parker, M. W., Carapetis, J. R., Van Melderen, L., Sriprakash, K. S., Smeesters, P. R., Batzloff, M., ... Tanz, R. (2014). A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. Journal of Infectious Diseases, 210(8), 1325-1338. https://doi.org/10.1093/infdis/jiu260

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title = "A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development",

abstract = "Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.",

keywords = "Epidemiology, Fibrinogen, IgA, IgG, M protein, Molecular typing, Plasminogen, Streptococcus pyogenes, Vaccine",

author = "Martina Sanderson-Smith and {De Oliveira}, {David M P} and Julien Guglielmini and McMillan, {David J.} and Therese Vu and Holien, {Jessica K.} and Anna Henningham and Steer, {Andrew C.} and Bessen, {Debra E.} and Dale, {James B.} and Nigel Curtis and Beall, {Bernard W.} and Walker, {Mark J.} and Parker, {Michael W.} and Carapetis, {Jonathan R.} and {Van Melderen}, Laurence and Sriprakash, {Kadaba S.} and Smeesters, {Pierre R.} and Michael Batzloff and Rebecca Towers and Herman Goossens and Surhbi Malhotra-Kumar and Luiza Guilherme and Rosangela Torres and Donald Low and Allison McGeer and Paula Krizova and {El Tayeb}, Sawsan and Joe Kado and {Van Der Linden}, Mark and Guliz Erdem and Alon Moses and Ran Nir-Paz and Tadayoshi Ikebe and Haruo Watanabe and Samba Sow and Boubou Tamboura and Bard Kittang and Jos{\'e} Melo-Cristino and Mario Ramirez and Monica Straut and Alexander Suvorov and Artem Totolian and Mark Engel and Bongani Mayosi and Andrew Whitelaw and Jessica Darenberg and Normark, {Birgitta Henriques} and Ni, {Chuan Chiang} and Wu, {Jiunn Jong} and {De Zoysa}, Aruni and Androulla Efstratiou and Stanford Shulman and Robert Tanz",

note = "Publisher Copyright: {\textcopyright} The Author 2014.",

year = "2014",

month = jan,

day = "1",

doi = "10.1093/infdis/jiu260",

language = "English (US)",

volume = "210",

pages = "1325--1338",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "8",

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Sanderson-Smith, M, De Oliveira, DMP, Guglielmini, J, McMillan, DJ, Vu, T, Holien, JK, Henningham, A, Steer, AC, Bessen, DE, Dale, JB, Curtis, N, Beall, BW, Walker, MJ, Parker, MW, Carapetis, JR, Van Melderen, L, Sriprakash, KS, Smeesters, PR, Batzloff, M, Towers, R, Goossens, H, Malhotra-Kumar, S, Guilherme, L, Torres, R, Low, D, McGeer, A, Krizova, P, El Tayeb, S, Kado, J, Van Der Linden, M, Erdem, G, Moses, A, Nir-Paz, R, Ikebe, T, Watanabe, H, Sow, S, Tamboura, B, Kittang, B, Melo-Cristino, J, Ramirez, M, Straut, M, Suvorov, A, Totolian, A, Engel, M, Mayosi, B, Whitelaw, A, Darenberg, J, Normark, BH, Ni, CC, Wu, JJ, De Zoysa, A, Efstratiou, A, Shulman, S & Tanz, R 2014, 'A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development', Journal of Infectious Diseases, vol. 210, no. 8, pp. 1325-1338. https://doi.org/10.1093/infdis/jiu260

TY - JOUR

T1 - A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

AU - Sanderson-Smith, Martina

AU - De Oliveira, David M P

AU - Guglielmini, Julien

AU - McMillan, David J.

AU - Vu, Therese

AU - Holien, Jessica K.

AU - Henningham, Anna

AU - Steer, Andrew C.

AU - Bessen, Debra E.

AU - Dale, James B.

AU - Curtis, Nigel

AU - Beall, Bernard W.

AU - Walker, Mark J.

AU - Parker, Michael W.

AU - Carapetis, Jonathan R.

AU - Van Melderen, Laurence

AU - Sriprakash, Kadaba S.

AU - Smeesters, Pierre R.

AU - Batzloff, Michael

AU - Towers, Rebecca

AU - Goossens, Herman

AU - Malhotra-Kumar, Surhbi

AU - Guilherme, Luiza

AU - Torres, Rosangela

AU - Low, Donald

AU - McGeer, Allison

AU - Krizova, Paula

AU - El Tayeb, Sawsan

AU - Kado, Joe

AU - Van Der Linden, Mark

AU - Erdem, Guliz

AU - Moses, Alon

AU - Nir-Paz, Ran

AU - Ikebe, Tadayoshi

AU - Watanabe, Haruo

AU - Sow, Samba

AU - Tamboura, Boubou

AU - Kittang, Bard

AU - Melo-Cristino, José

AU - Ramirez, Mario

AU - Straut, Monica

AU - Suvorov, Alexander

AU - Totolian, Artem

AU - Engel, Mark

AU - Mayosi, Bongani

AU - Whitelaw, Andrew

AU - Darenberg, Jessica

AU - Normark, Birgitta Henriques

AU - Ni, Chuan Chiang

AU - Wu, Jiunn Jong

AU - De Zoysa, Aruni

AU - Efstratiou, Androulla

AU - Shulman, Stanford

AU - Tanz, Robert

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.

AB - Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.

KW - Epidemiology

KW - Fibrinogen

KW - IgA

KW - IgG

KW - M protein

KW - Molecular typing

KW - Plasminogen

KW - Streptococcus pyogenes

KW - Vaccine

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UR - http://www.scopus.com/inward/citedby.url?scp=84910012882&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiu260

DO - 10.1093/infdis/jiu260

M3 - Article

C2 - 24799598

AN - SCOPUS:84910012882

SN - 0022-1899

VL - 210

SP - 1325

EP - 1338

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 8

ER -

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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