A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Martina Sanderson-Smith, David M P De Oliveira, Julien Guglielmini, David J. McMillan, Therese Vu, Jessica K. Holien, Anna Henningham, Andrew C. Steer, Debra E. Bessen, James B. Dale, Nigel Curtis, Bernard W. Beall, Mark J. Walker, Michael W. Parker, Jonathan R. Carapetis, Laurence Van Melderen, Kadaba S. Sriprakash, Pierre R. Smeesters*, Michael Batzloff, Rebecca Towers & 34 others Herman Goossens, Surhbi Malhotra-Kumar, Luiza Guilherme, Rosangela Torres, Donald Low, Allison McGeer, Paula Krizova, Sawsan El Tayeb, Joe Kado, Mark Van Der Linden, Guliz Erdem, Alon Moses, Ran Nir-Paz, Tadayoshi Ikebe, Haruo Watanabe, Samba Sow, Boubou Tamboura, Bard Kittang, José Melo-Cristino, Mario Ramirez, Monica Straut, Alexander Suvorov, Artem Totolian, Mark Engel, Bongani Mayosi, Andrew Whitelaw, Jessica Darenberg, Birgitta Henriques Normark, Chuan Chiang Ni, Jiunn Jong Wu, Aruni De Zoysa, Androulla Efstratiou, Stanford Shulman, Robert Tanz

*Corresponding author for this work

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.

Original languageEnglish (US)
Pages (from-to)1325-1338
Number of pages14
JournalJournal of Infectious Diseases
Volume210
Issue number8
DOIs
StatePublished - Jan 1 2014

Fingerprint

Molecular Typing
Synthetic Vaccines
Streptococcus pyogenes
Vaccines
Immunity
Rheumatic Heart Disease
Streptococcal Infections
Proteins
Virulence Factors
Bacterial Infections
Protein Binding
Virulence
Bacteria
Antigens
Mortality
streptococcal M protein

Keywords

  • Epidemiology
  • Fibrinogen
  • IgA
  • IgG
  • M protein
  • Molecular typing
  • Plasminogen
  • Streptococcus pyogenes
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Sanderson-Smith, Martina ; De Oliveira, David M P ; Guglielmini, Julien ; McMillan, David J. ; Vu, Therese ; Holien, Jessica K. ; Henningham, Anna ; Steer, Andrew C. ; Bessen, Debra E. ; Dale, James B. ; Curtis, Nigel ; Beall, Bernard W. ; Walker, Mark J. ; Parker, Michael W. ; Carapetis, Jonathan R. ; Van Melderen, Laurence ; Sriprakash, Kadaba S. ; Smeesters, Pierre R. ; Batzloff, Michael ; Towers, Rebecca ; Goossens, Herman ; Malhotra-Kumar, Surhbi ; Guilherme, Luiza ; Torres, Rosangela ; Low, Donald ; McGeer, Allison ; Krizova, Paula ; El Tayeb, Sawsan ; Kado, Joe ; Van Der Linden, Mark ; Erdem, Guliz ; Moses, Alon ; Nir-Paz, Ran ; Ikebe, Tadayoshi ; Watanabe, Haruo ; Sow, Samba ; Tamboura, Boubou ; Kittang, Bard ; Melo-Cristino, José ; Ramirez, Mario ; Straut, Monica ; Suvorov, Alexander ; Totolian, Artem ; Engel, Mark ; Mayosi, Bongani ; Whitelaw, Andrew ; Darenberg, Jessica ; Normark, Birgitta Henriques ; Ni, Chuan Chiang ; Wu, Jiunn Jong ; De Zoysa, Aruni ; Efstratiou, Androulla ; Shulman, Stanford ; Tanz, Robert. / A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. In: Journal of Infectious Diseases. 2014 ; Vol. 210, No. 8. pp. 1325-1338.
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abstract = "Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.",
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Sanderson-Smith, M, De Oliveira, DMP, Guglielmini, J, McMillan, DJ, Vu, T, Holien, JK, Henningham, A, Steer, AC, Bessen, DE, Dale, JB, Curtis, N, Beall, BW, Walker, MJ, Parker, MW, Carapetis, JR, Van Melderen, L, Sriprakash, KS, Smeesters, PR, Batzloff, M, Towers, R, Goossens, H, Malhotra-Kumar, S, Guilherme, L, Torres, R, Low, D, McGeer, A, Krizova, P, El Tayeb, S, Kado, J, Van Der Linden, M, Erdem, G, Moses, A, Nir-Paz, R, Ikebe, T, Watanabe, H, Sow, S, Tamboura, B, Kittang, B, Melo-Cristino, J, Ramirez, M, Straut, M, Suvorov, A, Totolian, A, Engel, M, Mayosi, B, Whitelaw, A, Darenberg, J, Normark, BH, Ni, CC, Wu, JJ, De Zoysa, A, Efstratiou, A, Shulman, S & Tanz, R 2014, 'A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development', Journal of Infectious Diseases, vol. 210, no. 8, pp. 1325-1338. https://doi.org/10.1093/infdis/jiu260

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. / Sanderson-Smith, Martina; De Oliveira, David M P; Guglielmini, Julien; McMillan, David J.; Vu, Therese; Holien, Jessica K.; Henningham, Anna; Steer, Andrew C.; Bessen, Debra E.; Dale, James B.; Curtis, Nigel; Beall, Bernard W.; Walker, Mark J.; Parker, Michael W.; Carapetis, Jonathan R.; Van Melderen, Laurence; Sriprakash, Kadaba S.; Smeesters, Pierre R.; Batzloff, Michael; Towers, Rebecca; Goossens, Herman; Malhotra-Kumar, Surhbi; Guilherme, Luiza; Torres, Rosangela; Low, Donald; McGeer, Allison; Krizova, Paula; El Tayeb, Sawsan; Kado, Joe; Van Der Linden, Mark; Erdem, Guliz; Moses, Alon; Nir-Paz, Ran; Ikebe, Tadayoshi; Watanabe, Haruo; Sow, Samba; Tamboura, Boubou; Kittang, Bard; Melo-Cristino, José; Ramirez, Mario; Straut, Monica; Suvorov, Alexander; Totolian, Artem; Engel, Mark; Mayosi, Bongani; Whitelaw, Andrew; Darenberg, Jessica; Normark, Birgitta Henriques; Ni, Chuan Chiang; Wu, Jiunn Jong; De Zoysa, Aruni; Efstratiou, Androulla; Shulman, Stanford; Tanz, Robert.

In: Journal of Infectious Diseases, Vol. 210, No. 8, 01.01.2014, p. 1325-1338.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

AU - Sanderson-Smith, Martina

AU - De Oliveira, David M P

AU - Guglielmini, Julien

AU - McMillan, David J.

AU - Vu, Therese

AU - Holien, Jessica K.

AU - Henningham, Anna

AU - Steer, Andrew C.

AU - Bessen, Debra E.

AU - Dale, James B.

AU - Curtis, Nigel

AU - Beall, Bernard W.

AU - Walker, Mark J.

AU - Parker, Michael W.

AU - Carapetis, Jonathan R.

AU - Van Melderen, Laurence

AU - Sriprakash, Kadaba S.

AU - Smeesters, Pierre R.

AU - Batzloff, Michael

AU - Towers, Rebecca

AU - Goossens, Herman

AU - Malhotra-Kumar, Surhbi

AU - Guilherme, Luiza

AU - Torres, Rosangela

AU - Low, Donald

AU - McGeer, Allison

AU - Krizova, Paula

AU - El Tayeb, Sawsan

AU - Kado, Joe

AU - Van Der Linden, Mark

AU - Erdem, Guliz

AU - Moses, Alon

AU - Nir-Paz, Ran

AU - Ikebe, Tadayoshi

AU - Watanabe, Haruo

AU - Sow, Samba

AU - Tamboura, Boubou

AU - Kittang, Bard

AU - Melo-Cristino, José

AU - Ramirez, Mario

AU - Straut, Monica

AU - Suvorov, Alexander

AU - Totolian, Artem

AU - Engel, Mark

AU - Mayosi, Bongani

AU - Whitelaw, Andrew

AU - Darenberg, Jessica

AU - Normark, Birgitta Henriques

AU - Ni, Chuan Chiang

AU - Wu, Jiunn Jong

AU - De Zoysa, Aruni

AU - Efstratiou, Androulla

AU - Shulman, Stanford

AU - Tanz, Robert

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.

AB - Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.

KW - Epidemiology

KW - Fibrinogen

KW - IgA

KW - IgG

KW - M protein

KW - Molecular typing

KW - Plasminogen

KW - Streptococcus pyogenes

KW - Vaccine

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JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

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