TY - JOUR
T1 - A Systematic Review of Research Gaps in the Evaluation and Management of Localized Renal Masses
AU - Patel, Hiten D.
AU - Iyoha, Emmanuel
AU - Pierorazio, Phillip M.
AU - Sozio, Stephen M.
AU - Johnson, Michael H.
AU - Sharma, Ritu
AU - Bass, Eric B.
AU - Allaf, Mohamad E.
N1 - Funding Information:
Financial Disclosure: Emmanuel Iyoha, Ritu Sharma, and Eric B. Bass are members of Evidence-Based Practice center, which was funded to conduct the systematic review by Contract No. HHSA290201200007I from the Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services. The remaining authors declare that they have no relevant financial interests.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - The management of clinically localized renal masses suspicious for renal cell carcinoma varies, partially because of gaps in the evidence base. We conducted a systematic review to summarize research gaps for the evaluation of composite models for predicting malignancy; use of percutaneous renal sampling for diagnosis; and comparative effectiveness of surgery, thermal ablation, and active surveillance. A total of 147 studies, published in 150 articles, were identified. To promote improved patient care and health outcomes, we recommend incorporation of emerging biomarkers into validated composite models, standardization of biopsy protocols, standard reporting of clinical stage, and performance of prospective studies with objective selection criteria.
AB - The management of clinically localized renal masses suspicious for renal cell carcinoma varies, partially because of gaps in the evidence base. We conducted a systematic review to summarize research gaps for the evaluation of composite models for predicting malignancy; use of percutaneous renal sampling for diagnosis; and comparative effectiveness of surgery, thermal ablation, and active surveillance. A total of 147 studies, published in 150 articles, were identified. To promote improved patient care and health outcomes, we recommend incorporation of emerging biomarkers into validated composite models, standardization of biopsy protocols, standard reporting of clinical stage, and performance of prospective studies with objective selection criteria.
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U2 - 10.1016/j.urology.2016.08.013
DO - 10.1016/j.urology.2016.08.013
M3 - Review article
C2 - 27542860
AN - SCOPUS:84994519218
SN - 0090-4295
VL - 98
SP - 14
EP - 20
JO - Urology
JF - Urology
ER -