A Systematic Review of Research Gaps in the Evaluation and Management of Localized Renal Masses

Hiten D. Patel; Emmanuel Iyoha; Phillip M. Pierorazio; Stephen M. Sozio; Michael H. Johnson; Ritu Sharma; Eric B. Bass; Mohamad E. Allaf

doi:10.1016/j.urology.2016.08.013

A Systematic Review of Research Gaps in the Evaluation and Management of Localized Renal Masses

Hiten D. Patel^*, Emmanuel Iyoha, Phillip M. Pierorazio, Stephen M. Sozio, Michael H. Johnson, Ritu Sharma, Eric B. Bass, Mohamad E. Allaf

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

The management of clinically localized renal masses suspicious for renal cell carcinoma varies, partially because of gaps in the evidence base. We conducted a systematic review to summarize research gaps for the evaluation of composite models for predicting malignancy; use of percutaneous renal sampling for diagnosis; and comparative effectiveness of surgery, thermal ablation, and active surveillance. A total of 147 studies, published in 150 articles, were identified. To promote improved patient care and health outcomes, we recommend incorporation of emerging biomarkers into validated composite models, standardization of biopsy protocols, standard reporting of clinical stage, and performance of prospective studies with objective selection criteria.

Original language	English (US)
Pages (from-to)	14-20
Number of pages	7
Journal	Urology
Volume	98
DOIs	https://doi.org/10.1016/j.urology.2016.08.013
State	Published - Dec 1 2016

Funding

Financial Disclosure: Emmanuel Iyoha, Ritu Sharma, and Eric B. Bass are members of Evidence-Based Practice center, which was funded to conduct the systematic review by Contract No. HHSA290201200007I from the Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services. The remaining authors declare that they have no relevant financial interests.

ASJC Scopus subject areas

Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.urology.2016.08.013

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title = "A Systematic Review of Research Gaps in the Evaluation and Management of Localized Renal Masses",

abstract = "The management of clinically localized renal masses suspicious for renal cell carcinoma varies, partially because of gaps in the evidence base. We conducted a systematic review to summarize research gaps for the evaluation of composite models for predicting malignancy; use of percutaneous renal sampling for diagnosis; and comparative effectiveness of surgery, thermal ablation, and active surveillance. A total of 147 studies, published in 150 articles, were identified. To promote improved patient care and health outcomes, we recommend incorporation of emerging biomarkers into validated composite models, standardization of biopsy protocols, standard reporting of clinical stage, and performance of prospective studies with objective selection criteria.",

author = "Patel, {Hiten D.} and Emmanuel Iyoha and Pierorazio, {Phillip M.} and Sozio, {Stephen M.} and Johnson, {Michael H.} and Ritu Sharma and Bass, {Eric B.} and Allaf, {Mohamad E.}",

note = "Funding Information: Financial Disclosure: Emmanuel Iyoha, Ritu Sharma, and Eric B. Bass are members of Evidence-Based Practice center, which was funded to conduct the systematic review by Contract No. HHSA290201200007I from the Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services. The remaining authors declare that they have no relevant financial interests. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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doi = "10.1016/j.urology.2016.08.013",

language = "English (US)",

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AU - Patel, Hiten D.

AU - Iyoha, Emmanuel

AU - Pierorazio, Phillip M.

AU - Sozio, Stephen M.

AU - Johnson, Michael H.

AU - Sharma, Ritu

AU - Bass, Eric B.

AU - Allaf, Mohamad E.

N1 - Funding Information: Financial Disclosure: Emmanuel Iyoha, Ritu Sharma, and Eric B. Bass are members of Evidence-Based Practice center, which was funded to conduct the systematic review by Contract No. HHSA290201200007I from the Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services. The remaining authors declare that they have no relevant financial interests. Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - The management of clinically localized renal masses suspicious for renal cell carcinoma varies, partially because of gaps in the evidence base. We conducted a systematic review to summarize research gaps for the evaluation of composite models for predicting malignancy; use of percutaneous renal sampling for diagnosis; and comparative effectiveness of surgery, thermal ablation, and active surveillance. A total of 147 studies, published in 150 articles, were identified. To promote improved patient care and health outcomes, we recommend incorporation of emerging biomarkers into validated composite models, standardization of biopsy protocols, standard reporting of clinical stage, and performance of prospective studies with objective selection criteria.

AB - The management of clinically localized renal masses suspicious for renal cell carcinoma varies, partially because of gaps in the evidence base. We conducted a systematic review to summarize research gaps for the evaluation of composite models for predicting malignancy; use of percutaneous renal sampling for diagnosis; and comparative effectiveness of surgery, thermal ablation, and active surveillance. A total of 147 studies, published in 150 articles, were identified. To promote improved patient care and health outcomes, we recommend incorporation of emerging biomarkers into validated composite models, standardization of biopsy protocols, standard reporting of clinical stage, and performance of prospective studies with objective selection criteria.

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SN - 0090-4295

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EP - 20

JO - Urology

JF - Urology

ER -

A Systematic Review of Research Gaps in the Evaluation and Management of Localized Renal Masses

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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