A tamoxifen receptor within a voltage-gated sodium channel

Altin Sula, David Hollingworth, Leo C.T. Ng, Megan Larmore, Paul G. DeCaen*, B. A. Wallace*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

X-ray crystallography and electrophysiology reveal the nature of the interactions of the drug tamoxifen (and its metabolic derivatives) with voltage-gated sodium channels.

Original languageEnglish (US)
Pages (from-to)1160-1169.e5
JournalMolecular cell
Volume81
Issue number6
DOIs
StatePublished - Mar 18 2021

Keywords

  • Channelopathies
  • Crystal Structure
  • Drug Binding
  • Electrophysiology
  • Estrogen Receptor
  • Novel Binding Site
  • Off-Target Drug Effects
  • Pharmacology
  • Tamoxifen
  • Voltage-gated Sodium Channels

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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