@article{3267cf153aab4fd5b6b0e1999607b4c8,
title = "A tamoxifen receptor within a voltage-gated sodium channel",
abstract = "X-ray crystallography and electrophysiology reveal the nature of the interactions of the drug tamoxifen (and its metabolic derivatives) with voltage-gated sodium channels.",
keywords = "Channelopathies, Crystal Structure, Drug Binding, Electrophysiology, Estrogen Receptor, Novel Binding Site, Off-Target Drug Effects, Pharmacology, Tamoxifen, Voltage-gated Sodium Channels",
author = "Altin Sula and David Hollingworth and Ng, {Leo C.T.} and Megan Larmore and DeCaen, {Paul G.} and Wallace, {B. A.}",
note = "Funding Information: We thank the staff at the P13 (European Molecular Biology Laboratory [EMBL], Hamburg, Germany) and I04, I03, I24 (Diamond Light Source) beamlines for assistance during data collection and Dina Molner (Birkbeck) for help in making the F208L mutant. This work was supported by grants BB/L006790, BB/N012763, and BB/R001294 from the U.K. Biotechnology and Biological Science Research Council (BBSRC) to B.A.W.; a grant from the Rosetrees Trust to B.A.W.; a grant from the National Institute of Academic Anaesthesia to B.A.W., H. Hemmings, and K.F. Herold; crystallography beamtime grants to the Birkbeck/UCL BAG consortium from the EMBL, Hamburg, and the Diamond Light Source; and an iNEXT grant for travel to the P13 beamline. P.G.D. was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ( 1R56DK119709-01 , 4R00DK106655 , 1R01 DK123463-01 , and P30 DK090728 ), NU GoKidney George M. O{\textquoteright}Brien Kidney Research Core Center ( P30 DK11485 ), and the American Society of Nephrology (Carl W. Gottschalk Scholar Award). Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = mar,
day = "18",
doi = "10.1016/j.molcel.2020.12.048",
language = "English (US)",
volume = "81",
pages = "1160--1169.e5",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "6",
}