Abstract
X-ray crystallography and electrophysiology reveal the nature of the interactions of the drug tamoxifen (and its metabolic derivatives) with voltage-gated sodium channels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1160-1169.e5 |
| Journal | Molecular cell |
| Volume | 81 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 18 2021 |
Keywords
- Channelopathies
- Crystal Structure
- Drug Binding
- Electrophysiology
- Estrogen Receptor
- Novel Binding Site
- Off-Target Drug Effects
- Pharmacology
- Tamoxifen
- Voltage-gated Sodium Channels
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
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Dive into the research topics of 'A tamoxifen receptor within a voltage-gated sodium channel'. Together they form a unique fingerprint.Datasets
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Crystal Structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with N-desmethyltamoxifen (3.2 A resolution)
Sula, A. (Contributor), Hollingworth, D. (Contributor), Ng, L. C. T. (Contributor), Larmore, M. (Contributor), DeCaen, P. G. (Contributor) & Wallace, B. A. (Contributor), Protein Data Bank (PDB), Feb 3 2021
DOI: 10.2210/pdb6Z8C/pdb, https://www.wwpdb.org/pdb?id=pdb_00006z8c
Dataset
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Crystal Structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with Endoxifen (2.6 Angstrom resolution)
Sula, A. (Contributor), Hollingworth, D. (Contributor), Ng, L. C. T. (Contributor), Larmore, M. (Contributor), DeCaen, P. G. (Contributor) & Wallace, B. A. (Contributor), Protein Data Bank (PDB), Feb 3 2021
DOI: 10.2210/pdb6SXE/pdb, https://www.wwpdb.org/pdb?id=pdb_00006sxe
Dataset
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Crystal Structure of the Voltage-Gated Sodium Channel NavMs in complex with 4-hydroxytamoxifen (2.4 Angstrom resolution)
Sula, A. (Contributor), Hollingworth, D. (Contributor), Ng, L. C. T. (Contributor), Larmore, M. (Contributor), DeCaen, P. G. (Contributor) & Wallace, B. A. (Contributor), Protein Data Bank (PDB), Feb 3 2021
DOI: 10.2210/pdb6SXG/pdb, https://www.wwpdb.org/pdb?id=pdb_00006sxg
Dataset