A temporo-spatial regulation of sema3c is essential for interaction of progenitor cells during cardiac outflow tract development

Kazuki Kodo, Shinsuke Shibata, Sachiko Miyagawa-Tomita, Sang Ging Ong, Hiroshi Takahashi, Tsutomu Kume, Hideyuki Okano, Rumiko Matsuoka, Hiroyuki Yamagishi*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The two cardiac progenitor cell lineages, cardiac neural crest cells (cNCCs) and the second heart field (SHF), play key roles in the development of the cardiac outflow tract (OFT). Both cardiac progenitor cells interact with each other and contribute to OFT formation cooperatively. The neurovascular guiding molecule, semaphorin 3c (Sema3c), is thought to serve as a key attractant for the migration of cNCCs. A previous study reported that Tbx1 null mice showed a significant reduction in Sema3c expression in the OFT region [1]. However, the regulatory effect of Tbx1 on Sema3c was unclear. Here, we show that Sema3c plays key roles in cNCCs-SHF interactions through the regulation by Tbx1 and other molecules during OFT development [2].

Original languageEnglish (US)
Title of host publicationMolecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
PublisherSpringer Singapore
Pages377-379
Number of pages3
ISBN (Electronic)9789811511851
ISBN (Print)9789811511844
DOIs
StatePublished - Jan 1 2020

Keywords

  • Cardiac neural crest cell
  • Congenital heart disease
  • Second heart field
  • TBX1

ASJC Scopus subject areas

  • Medicine(all)

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    Kodo, K., Shibata, S., Miyagawa-Tomita, S., Ong, S. G., Takahashi, H., Kume, T., Okano, H., Matsuoka, R., & Yamagishi, H. (2020). A temporo-spatial regulation of sema3c is essential for interaction of progenitor cells during cardiac outflow tract development. In Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension (pp. 377-379). Springer Singapore. https://doi.org/10.1007/978-981-15-1185-1_58