A theoretical framework for retrospective T2∗ correction to the arterial input function in quantitative myocardial perfusion MRI

Lexiaozi Fan*, Bradley D. Allen, Austin E. Culver, Li Yueh Hsu, Kyungpyo Hong, Brandon C. Benefield, James C. Carr, Daniel C. Lee, Daniel Kim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To develop and evaluate a flexible, Bloch-equation based framework for retrospective (Formula presented.) correction to the arterial input function (AIF) obtained with quantitative cardiac perfusion pulse sequences. Methods: Our framework initially calculates the gadolinium concentration [Gd] based on T1 measurements alone. Next, (Formula presented.) is estimated from this initial calculation of [Gd] while assuming fast water exchange and using the literature native T2 and static magnetic field variation (ΔB0) values. Finally, the [Gd] is recalculated after performing (Formula presented.) correction to the Bloch equation signal model. Using this approach, we performed (Formula presented.) correction to historical phantom and in vivo, dual-imaging perfusion data sets from 3 different patient groups obtained using different pulse sequences and imaging parameters. Images were processed to quantify both the AIF and resting myocardial blood flow (MBF). We also performed a sensitivity analysis of our (Formula presented.) correction to ±20% variations in native T2 and ΔB0. Results: Compared with the ground truth [Gd] of phantom, the normalized root-means-square-error (NRMSE) in measured [Gd] was 5.1%, 1.3%, and 0.6% for uncorrected, our corrected, and Kellman’s corrected, respectively. For in vivo data, both the peak AIF (7.0 ± 3.0 mM vs. 8.6 ± 7.1 mM, 7.2 ± 0.9 mM vs. 8.6 ± 1.7 mM, 7.7 ± 1.8 mM vs. 10.3 ± 5.1 mM, P <.001) and resting MBF (1.3 ± 0.1 mL/g/min vs. 1.1 ± 0.1 mL/g/min, 1.3 ± 0.1 mL/g/min vs. 1.1 ± 0.1 mL/g/min, 1.2 ± 0.1 mL/g/min vs. 0.9 ± 0.1 mL/g/min, P <.001) values were significantly different between uncorrected and corrected for all 3 patient groups. Both the peak AIF and resting MBF values varied by <5% over the said variations in native T2 and ΔB0. Conclusion: Our theoretical framework enables retrospective (Formula presented.) correction to the AIF obtained with dual-imaging, cardiac perfusion pulse sequences.

Original languageEnglish (US)
Pages (from-to)1137-1144
Number of pages8
JournalMagnetic resonance in medicine
Volume86
Issue number2
DOIs
StatePublished - Aug 2021

Keywords

  • T2∗ correction
  • arterial input function
  • myocardial blood flow
  • perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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