A thoroughly modern gage

Mariana Dimitrov, Michael Phipps, Theodore P. Zahn, Jordan Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

We describe a 50-year-old male patient (MGS) with a right frontal ventromedial lesion who showed preserved general cognitive, abstract thinking and problem-solving abilities, in contrast to gross impairment in his social competence, social decision making and social conduct. MGS also demonstrated diminished sensitivity to socially relevant stimuli and situational nuances, impairment in sexual behavior, lost sense of responsibility, and disinhibition. We interpret his neurobehavioral profile, identical to the one of the famous 19th century patient Phineas Gage, in the light of the hypothesis that emotion and social conduct regulation depend on the ventromedial frontal cortex.

Original languageEnglish (US)
Pages (from-to)345-354
Number of pages10
JournalNeurocase
Volume5
Issue number4
DOIs
StatePublished - Sep 1 1999

Fingerprint

Aptitude
Frontal Lobe
Sexual Behavior
Decision Making
Emotions
Impairment
Thinking
Social Skills
Social Competence
Responsibility
Situational
Lesion
Cortex
Problem Solving
Stimulus
Emotion

Keywords

  • Orbitofrontal
  • Social cognition
  • Ventromedial frontal

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Dimitrov, M., Phipps, M., Zahn, T. P., & Grafman, J. (1999). A thoroughly modern gage. Neurocase, 5(4), 345-354. https://doi.org/10.1093/neucas/5.4.345
Dimitrov, Mariana ; Phipps, Michael ; Zahn, Theodore P. ; Grafman, Jordan. / A thoroughly modern gage. In: Neurocase. 1999 ; Vol. 5, No. 4. pp. 345-354.
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Dimitrov, M, Phipps, M, Zahn, TP & Grafman, J 1999, 'A thoroughly modern gage', Neurocase, vol. 5, no. 4, pp. 345-354. https://doi.org/10.1093/neucas/5.4.345

A thoroughly modern gage. / Dimitrov, Mariana; Phipps, Michael; Zahn, Theodore P.; Grafman, Jordan.

In: Neurocase, Vol. 5, No. 4, 01.09.1999, p. 345-354.

Research output: Contribution to journalArticle

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Dimitrov M, Phipps M, Zahn TP, Grafman J. A thoroughly modern gage. Neurocase. 1999 Sep 1;5(4):345-354. https://doi.org/10.1093/neucas/5.4.345