A thoroughly modern gage

Mariana Dimitrov, Michael Phipps, Theodore P. Zahn, Jordan Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


We describe a 50-year-old male patient (MGS) with a right frontal ventromedial lesion who showed preserved general cognitive, abstract thinking and problem-solving abilities, in contrast to gross impairment in his social competence, social decision making and social conduct. MGS also demonstrated diminished sensitivity to socially relevant stimuli and situational nuances, impairment in sexual behavior, lost sense of responsibility, and disinhibition. We interpret his neurobehavioral profile, identical to the one of the famous 19th century patient Phineas Gage, in the light of the hypothesis that emotion and social conduct regulation depend on the ventromedial frontal cortex.

Original languageEnglish (US)
Pages (from-to)345-354
Number of pages10
Issue number4
StatePublished - Sep 1 1999


  • Orbitofrontal
  • Social cognition
  • Ventromedial frontal

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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