A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care

Jeffrey Haspel*, Minjee Kim, Phyllis Zee, Tanja Schwarzmeier, Sara Montagnese, Satchidananda Panda, Adriana Albani, Martha Merrow

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

We currently find ourselves in the midst of a global coronavirus disease 2019 (COVID-19) pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss aspects of SARS-CoV-2 biology and pathology and how these might interact with the circadian clock of the host. We further focus on the severe manifestation of the illness, leading to hospitalization in an intensive care unit. The most common severe complications of COVID-19 relate to clock-regulated human physiology. We speculate on how the pandemic might be used to gain insights on the circadian clock but, more importantly, on how knowledge of the circadian clock might be used to mitigate the disease expression and the clinical course of COVID-19.

Original languageEnglish (US)
Pages (from-to)55-70
Number of pages16
JournalJournal of biological rhythms
Volume36
Issue number1
DOIs
StatePublished - Feb 2021

Keywords

  • COVID-19
  • SARS-CoV-2
  • circadian clock
  • critical care
  • nutrition
  • rhythm
  • zeitgeber

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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