TY - JOUR
T1 - A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy
AU - Choi, Yeon Sik
AU - Jeong, Hyoyoung
AU - Yin, Rose T.
AU - Avila, Raudel
AU - Pfenniger, Anna
AU - Yoo, Jaeyoung
AU - Lee, Jong Yoon
AU - Tzavelis, Andreas
AU - Lee, Young Joong
AU - Chen, Sheena W.
AU - Knight, Helen S.
AU - Kim, Seungyeob
AU - Ahn, Hak Young
AU - Wickerson, Grace
AU - Vázquez-Guardado, Abraham
AU - Higbee-Dempsey, Elizabeth
AU - Russo, Bender A.
AU - Napolitano, Michael A.
AU - Holleran, Timothy J.
AU - Razzak, Leen Abdul
AU - Miniovich, Alana N.
AU - Lee, Geumbee
AU - Geist, Beth
AU - Kim, Brandon
AU - Han, Shuling
AU - Brennan, Jaclyn A.
AU - Aras, Kedar
AU - Kwak, Sung Soo
AU - Kim, Joohee
AU - Waters, Emily Alexandria
AU - Yang, Xiangxing
AU - Burrell, Amy
AU - Chun, Keum San
AU - Liu, Claire
AU - Wu, Changsheng
AU - Rwei, Alina Y.
AU - Spann, Alisha N.
AU - Banks, Anthony
AU - Johnson, David
AU - Zhang, Zheng Jenny
AU - Haney, Chad R.
AU - Jin, Sung Hun
AU - Sahakian, Alan Varteres
AU - Huang, Yonggang
AU - Trachiotis, Gregory D.
AU - Knight, Bradley P.
AU - Arora, Rishi K.
AU - Efimov, Igor R.
AU - Rogers, John A.
N1 - Funding Information:
This work was funded by National Institutes of Health grants 1K99HL155844-01A1 (Y.S.C.), R01-HL141470 (I.R.E. and J.A.R.), R01 HL140061 (R.K.A.), R01 HL125881 (R.K.A.), KL2TR001424 (A.P.), F30HL157066 (A.T.), and 5K99-HL148523-02 (K.A.); Ministry of Health & Welfare, Republic of Korea (Korea Health Industry Development Institute), grant HI19C1348 (Y.S.C. and H.-Y.A.); Leducq Foundation project RHYTHM (I.R.E. and J.A.R.); American Heart Association 18SFRN34110170 (R.K.A.); American Heart Association Predoctoral Fellowship 19PRE34380781 (R.T.Y.); National Science Foundation Graduate Research Fellowship 1842165 (R.A.); a Ford Foundation Predoctoral Fellowship (R.A.); Chan Zuckerberg Initiative DAF grant 2020-225578 (E.A.W.); and an advised fund of the Silicon Valley Community Foundation (E A W)
Publisher Copyright:
© 2022 American Association for the Advancement of Science. All rights reserved.
PY - 2022/5/27
Y1 - 2022/5/27
N2 - Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.
AB - Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.
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U2 - 10.1126/science.abm1703
DO - 10.1126/science.abm1703
M3 - Article
C2 - 35617386
AN - SCOPUS:85130974722
SN - 0036-8075
VL - 376
SP - 1006
EP - 1012
JO - Science
JF - Science
IS - 6596
ER -