A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy

Yeon Sik Choi; Hyoyoung Jeong; Rose T. Yin; Raudel Avila; Anna Pfenniger; Jaeyoung Yoo; Jong Yoon Lee; Andreas Tzavelis; Young Joong Lee; Sheena W. Chen; Helen S. Knight; Seungyeob Kim; Hak Young Ahn; Grace Wickerson; Abraham Vázquez-Guardado; Elizabeth Higbee-Dempsey; Bender A. Russo; Michael A. Napolitano; Timothy J. Holleran; Leen Abdul Razzak; Alana N. Miniovich; Geumbee Lee; Beth Geist; Brandon Kim; Shuling Han; Jaclyn A. Brennan; Kedar Aras; Sung Soo Kwak; Joohee Kim; Emily Alexandria Waters; Xiangxing Yang; Amy Burrell; Keum San Chun; Claire Liu; Changsheng Wu; Alina Y. Rwei; Alisha N. Spann; Anthony Banks; David Johnson; Zheng Jenny Zhang; Chad R. Haney; Sung Hun Jin; Alan Varteres Sahakian; Yonggang Huang; Gregory D. Trachiotis; Bradley P. Knight; Rishi K. Arora; Igor R. Efimov; John A. Rogers

doi:10.1126/science.abm1703

A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy

Yeon Sik Choi, Hyoyoung Jeong, Rose T. Yin, Raudel Avila, Anna Pfenniger, Jaeyoung Yoo, Jong Yoon Lee, Andreas Tzavelis, Young Joong Lee, Sheena W. Chen, Helen S. Knight, Seungyeob Kim, Hak Young Ahn, Grace Wickerson, Abraham Vázquez-Guardado, Elizabeth Higbee-Dempsey, Bender A. Russo, Michael A. Napolitano, Timothy J. Holleran, Leen Abdul RazzakAlana N. Miniovich, Geumbee Lee, Beth Geist, Brandon Kim, Shuling Han, Jaclyn A. Brennan, Kedar Aras, Sung Soo Kwak, Joohee Kim, Emily Alexandria Waters, Xiangxing Yang, Amy Burrell, Keum San Chun, Claire Liu, Changsheng Wu, Alina Y. Rwei, Alisha N. Spann, Anthony Banks, David Johnson, Zheng Jenny Zhang, Chad R. Haney, Sung Hun Jin, Alan Varteres Sahakian, Yonggang Huang, Gregory D. Trachiotis, Bradley P. Knight, Rishi K. Arora^*, Igor R. Efimov, John A. Rogers

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

170 Scopus citations

Abstract

Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.

Original language	English (US)
Pages (from-to)	1006-1012
Number of pages	7
Journal	Science
Volume	376
Issue number	6596
DOIs	https://doi.org/10.1126/science.abm1703
State	Published - May 27 2022

Funding

This work was funded by National Institutes of Health grants 1K99HL155844-01A1 (Y.S.C.), R01-HL141470 (I.R.E. and J.A.R.), R01 HL140061 (R.K.A.), R01 HL125881 (R.K.A.), KL2TR001424 (A.P.), F30HL157066 (A.T.), and 5K99-HL148523-02 (K.A.); Ministry of Health & Welfare, Republic of Korea (Korea Health Industry Development Institute), grant HI19C1348 (Y.S.C. and H.-Y.A.); Leducq Foundation project RHYTHM (I.R.E. and J.A.R.); American Heart Association 18SFRN34110170 (R.K.A.); American Heart Association Predoctoral Fellowship 19PRE34380781 (R.T.Y.); National Science Foundation Graduate Research Fellowship 1842165 (R.A.); a Ford Foundation Predoctoral Fellowship (R.A.); Chan Zuckerberg Initiative DAF grant 2020-225578 (E.A.W.); and an advised fund of the Silicon Valley Community Foundation (E A W)

ASJC Scopus subject areas

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10.1126/science.abm1703

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Choi, Y. S., Jeong, H., Yin, R. T., Avila, R., Pfenniger, A., Yoo, J., Lee, J. Y., Tzavelis, A., Lee, Y. J., Chen, S. W., Knight, H. S., Kim, S., Ahn, H. Y., Wickerson, G., Vázquez-Guardado, A., Higbee-Dempsey, E., Russo, B. A., Napolitano, M. A., Holleran, T. J., ... Rogers, J. A. (2022). A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy. Science, 376(6596), 1006-1012. https://doi.org/10.1126/science.abm1703

@article{4efcd8e3fbbf465b830358892a647bc1,

title = "A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy",

abstract = "Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.",

author = "Choi, {Yeon Sik} and Hyoyoung Jeong and Yin, {Rose T.} and Raudel Avila and Anna Pfenniger and Jaeyoung Yoo and Lee, {Jong Yoon} and Andreas Tzavelis and Lee, {Young Joong} and Chen, {Sheena W.} and Knight, {Helen S.} and Seungyeob Kim and Ahn, {Hak Young} and Grace Wickerson and Abraham V{\'a}zquez-Guardado and Elizabeth Higbee-Dempsey and Russo, {Bender A.} and Napolitano, {Michael A.} and Holleran, {Timothy J.} and Razzak, {Leen Abdul} and Miniovich, {Alana N.} and Geumbee Lee and Beth Geist and Brandon Kim and Shuling Han and Brennan, {Jaclyn A.} and Kedar Aras and Kwak, {Sung Soo} and Joohee Kim and Waters, {Emily Alexandria} and Xiangxing Yang and Amy Burrell and Chun, {Keum San} and Claire Liu and Changsheng Wu and Rwei, {Alina Y.} and Spann, {Alisha N.} and Anthony Banks and David Johnson and Zhang, {Zheng Jenny} and Haney, {Chad R.} and Jin, {Sung Hun} and Sahakian, {Alan Varteres} and Yonggang Huang and Trachiotis, {Gregory D.} and Knight, {Bradley P.} and Arora, {Rishi K.} and Efimov, {Igor R.} and Rogers, {John A.}",

note = "Funding Information: This work was funded by National Institutes of Health grants 1K99HL155844-01A1 (Y.S.C.), R01-HL141470 (I.R.E. and J.A.R.), R01 HL140061 (R.K.A.), R01 HL125881 (R.K.A.), KL2TR001424 (A.P.), F30HL157066 (A.T.), and 5K99-HL148523-02 (K.A.); Ministry of Health & Welfare, Republic of Korea (Korea Health Industry Development Institute), grant HI19C1348 (Y.S.C. and H.-Y.A.); Leducq Foundation project RHYTHM (I.R.E. and J.A.R.); American Heart Association 18SFRN34110170 (R.K.A.); American Heart Association Predoctoral Fellowship 19PRE34380781 (R.T.Y.); National Science Foundation Graduate Research Fellowship 1842165 (R.A.); a Ford Foundation Predoctoral Fellowship (R.A.); Chan Zuckerberg Initiative DAF grant 2020-225578 (E.A.W.); and an advised fund of the Silicon Valley Community Foundation (E A W) Publisher Copyright: {\textcopyright} 2022 American Association for the Advancement of Science. All rights reserved.",

year = "2022",

month = may,

day = "27",

doi = "10.1126/science.abm1703",

language = "English (US)",

volume = "376",

pages = "1006--1012",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6596",

}

Choi, YS, Jeong, H, Yin, RT, Avila, R, Pfenniger, A, Yoo, J, Lee, JY, Tzavelis, A, Lee, YJ, Chen, SW, Knight, HS, Kim, S, Ahn, HY, Wickerson, G, Vázquez-Guardado, A, Higbee-Dempsey, E, Russo, BA, Napolitano, MA, Holleran, TJ, Razzak, LA, Miniovich, AN, Lee, G, Geist, B, Kim, B, Han, S, Brennan, JA, Aras, K, Kwak, SS, Kim, J, Waters, EA, Yang, X, Burrell, A, Chun, KS, Liu, C, Wu, C, Rwei, AY, Spann, AN, Banks, A, Johnson, D, Zhang, ZJ , Haney, CR, Jin, SH, Sahakian, AV , Huang, Y, Trachiotis, GD, Knight, BP, Arora, RK, Efimov, IR & Rogers, JA 2022, 'A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy', Science, vol. 376, no. 6596, pp. 1006-1012. https://doi.org/10.1126/science.abm1703

TY - JOUR

T1 - A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy

AU - Choi, Yeon Sik

AU - Jeong, Hyoyoung

AU - Yin, Rose T.

AU - Avila, Raudel

AU - Pfenniger, Anna

AU - Yoo, Jaeyoung

AU - Lee, Jong Yoon

AU - Tzavelis, Andreas

AU - Lee, Young Joong

AU - Chen, Sheena W.

AU - Knight, Helen S.

AU - Kim, Seungyeob

AU - Ahn, Hak Young

AU - Wickerson, Grace

AU - Vázquez-Guardado, Abraham

AU - Higbee-Dempsey, Elizabeth

AU - Russo, Bender A.

AU - Napolitano, Michael A.

AU - Holleran, Timothy J.

AU - Razzak, Leen Abdul

AU - Miniovich, Alana N.

AU - Lee, Geumbee

AU - Geist, Beth

AU - Kim, Brandon

AU - Han, Shuling

AU - Brennan, Jaclyn A.

AU - Aras, Kedar

AU - Kwak, Sung Soo

AU - Kim, Joohee

AU - Waters, Emily Alexandria

AU - Yang, Xiangxing

AU - Burrell, Amy

AU - Chun, Keum San

AU - Liu, Claire

AU - Wu, Changsheng

AU - Rwei, Alina Y.

AU - Spann, Alisha N.

AU - Banks, Anthony

AU - Johnson, David

AU - Zhang, Zheng Jenny

AU - Haney, Chad R.

AU - Jin, Sung Hun

AU - Sahakian, Alan Varteres

AU - Huang, Yonggang

AU - Trachiotis, Gregory D.

AU - Knight, Bradley P.

AU - Arora, Rishi K.

AU - Efimov, Igor R.

AU - Rogers, John A.

N1 - Funding Information: This work was funded by National Institutes of Health grants 1K99HL155844-01A1 (Y.S.C.), R01-HL141470 (I.R.E. and J.A.R.), R01 HL140061 (R.K.A.), R01 HL125881 (R.K.A.), KL2TR001424 (A.P.), F30HL157066 (A.T.), and 5K99-HL148523-02 (K.A.); Ministry of Health & Welfare, Republic of Korea (Korea Health Industry Development Institute), grant HI19C1348 (Y.S.C. and H.-Y.A.); Leducq Foundation project RHYTHM (I.R.E. and J.A.R.); American Heart Association 18SFRN34110170 (R.K.A.); American Heart Association Predoctoral Fellowship 19PRE34380781 (R.T.Y.); National Science Foundation Graduate Research Fellowship 1842165 (R.A.); a Ford Foundation Predoctoral Fellowship (R.A.); Chan Zuckerberg Initiative DAF grant 2020-225578 (E.A.W.); and an advised fund of the Silicon Valley Community Foundation (E A W) Publisher Copyright: © 2022 American Association for the Advancement of Science. All rights reserved.

PY - 2022/5/27

Y1 - 2022/5/27

N2 - Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.

AB - Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.

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UR - http://www.scopus.com/inward/citedby.url?scp=85130974722&partnerID=8YFLogxK

U2 - 10.1126/science.abm1703

DO - 10.1126/science.abm1703

M3 - Article

C2 - 35617386

AN - SCOPUS:85130974722

SN - 0036-8075

VL - 376

SP - 1006

EP - 1012

JO - Science

JF - Science

IS - 6596

ER -

A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy

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