A transient embryonic dopamine receptor inhibits growth cone motility and neurite outgrowth in a subset of avian retina neurons

Karen Lankford; Fernando G. De Mello; William L. Klein

doi:10.1016/0304-3940(87)90292-8

A transient embryonic dopamine receptor inhibits growth cone motility and neurite outgrowth in a subset of avian retina neurons

Karen Lankford^*, Fernando G. De Mello, William L. Klein

^*Corresponding author for this work

Neurobiology

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

To investigate the possible developmental significance of a transient dopamine receptor in the avian central nervous system, we examined the effects of dopamine on the morphology and motility of cultured retina neurons. Neurite arborization was significantly reduced by chronic dopamine stimulation. Using continuous video microscope monitoring, we observed that a subset of neurons responded to short-term dopamine with decreased filopodial activity and retracted neurites. The effects of dopamine could be blocked or reversed by haloperidol or SCH23390 and forskolin produced a response similar to dopamine, indicating the morphological changes were mediated by D₁-receptor stimulation of adenylate cyclase.

Original language	English (US)
Pages (from-to)	169-174
Number of pages	6
Journal	Neuroscience Letters
Volume	75
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(87)90292-8
State	Published - Mar 31 1987

Keywords

Axon
Dendrite
Synaptogenesis
Vertebrate

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/0304-3940(87)90292-8

Cite this

@article{15175c758c8e49058959671f2874c7d3,

title = "A transient embryonic dopamine receptor inhibits growth cone motility and neurite outgrowth in a subset of avian retina neurons",

abstract = "To investigate the possible developmental significance of a transient dopamine receptor in the avian central nervous system, we examined the effects of dopamine on the morphology and motility of cultured retina neurons. Neurite arborization was significantly reduced by chronic dopamine stimulation. Using continuous video microscope monitoring, we observed that a subset of neurons responded to short-term dopamine with decreased filopodial activity and retracted neurites. The effects of dopamine could be blocked or reversed by haloperidol or SCH23390 and forskolin produced a response similar to dopamine, indicating the morphological changes were mediated by D1-receptor stimulation of adenylate cyclase.",

keywords = "Axon, Dendrite, Synaptogenesis, Vertebrate",

author = "Karen Lankford and {De Mello}, {Fernando G.} and Klein, {William L.}",

note = "Funding Information: This work was supported by NIH Grant NS21088 to W.L.K.F.G.D.M. is a Guggenheim Fellow on leave from the Federal University of Rio de Janeiro. K.L. was supported in part by NIH training Grant T32-HD07068.",

year = "1987",

month = mar,

day = "31",

doi = "10.1016/0304-3940(87)90292-8",

language = "English (US)",

volume = "75",

pages = "169--174",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - A transient embryonic dopamine receptor inhibits growth cone motility and neurite outgrowth in a subset of avian retina neurons

AU - Lankford, Karen

AU - De Mello, Fernando G.

AU - Klein, William L.

N1 - Funding Information: This work was supported by NIH Grant NS21088 to W.L.K.F.G.D.M. is a Guggenheim Fellow on leave from the Federal University of Rio de Janeiro. K.L. was supported in part by NIH training Grant T32-HD07068.

PY - 1987/3/31

Y1 - 1987/3/31

N2 - To investigate the possible developmental significance of a transient dopamine receptor in the avian central nervous system, we examined the effects of dopamine on the morphology and motility of cultured retina neurons. Neurite arborization was significantly reduced by chronic dopamine stimulation. Using continuous video microscope monitoring, we observed that a subset of neurons responded to short-term dopamine with decreased filopodial activity and retracted neurites. The effects of dopamine could be blocked or reversed by haloperidol or SCH23390 and forskolin produced a response similar to dopamine, indicating the morphological changes were mediated by D1-receptor stimulation of adenylate cyclase.

AB - To investigate the possible developmental significance of a transient dopamine receptor in the avian central nervous system, we examined the effects of dopamine on the morphology and motility of cultured retina neurons. Neurite arborization was significantly reduced by chronic dopamine stimulation. Using continuous video microscope monitoring, we observed that a subset of neurons responded to short-term dopamine with decreased filopodial activity and retracted neurites. The effects of dopamine could be blocked or reversed by haloperidol or SCH23390 and forskolin produced a response similar to dopamine, indicating the morphological changes were mediated by D1-receptor stimulation of adenylate cyclase.

KW - Axon

KW - Dendrite

KW - Synaptogenesis

KW - Vertebrate

UR - http://www.scopus.com/inward/record.url?scp=0023092532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023092532&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(87)90292-8

DO - 10.1016/0304-3940(87)90292-8

M3 - Article

C2 - 2952906

AN - SCOPUS:0023092532

SN - 0304-3940

VL - 75

SP - 169

EP - 174

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

A transient embryonic dopamine receptor inhibits growth cone motility and neurite outgrowth in a subset of avian retina neurons

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this