A tumor necrosis factor-α-inducible promoter variant of interferon-γ accelerates CD4+ t cell depletion in human immunodeficiency virus-1-infected individuals

Ping An, David Vlahov, Joseph B. Margolick, John Phair, Thomas R. O'Brien, James Lautenberger, Stephen J. O'Brien, Cheryl A. Winkler*

*Corresponding author for this work

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

A polymorphism, -179G/T, in the promoter of the interferon (IFN)-γ gene (IFNG) confers differential tumor necrosis factor-α (TNF-α) inducibility to the IFNG promoter. The rarer allele, -179T, but not -179G, is inducible by TNF-α. We investigated the effects of IFNG -179G/T on AIDS pathogenesis. In 298 African American human immunodeficiency virus (HIV)-1 seroconverters, the IFNG -179G/T genotype was associated with accelerated progression to CD4 <200 and AIDS-1993, a finding suggesting that IFNG -179T is a risk factor for AIDS progression, as measured by CD4 cell count. It is possible that increased IFN-γ production induced by TNF-α when -179T is present causes CD4 cell depletion by apoptosis.

Original languageEnglish (US)
Pages (from-to)228-231
Number of pages4
JournalJournal of Infectious Diseases
Volume188
Issue number2
DOIs
StatePublished - Jul 15 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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