A Tumor Suppressor SIRTainty

Paul T. Schumacker

doi:10.1016/j.ccr.2009.12.032

A Tumor Suppressor SIRTainty

Paul T. Schumacker^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Short survey

19 Scopus citations

Abstract

Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.

Original language	English (US)
Pages (from-to)	5-6
Number of pages	2
Journal	Cancer Cell
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.ccr.2009.12.032
State	Published - Jan 19 2010

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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Schumacker, P. T. (2010). A Tumor Suppressor SIRTainty. Cancer Cell, 17(1), 5-6. https://doi.org/10.1016/j.ccr.2009.12.032

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