A Tumor Suppressor SIRTainty

Paul T. Schumacker

doi:10.1016/j.ccr.2009.12.032

A Tumor Suppressor SIRTainty

Paul T. Schumacker^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Short survey › peer-review

20 Scopus citations

Abstract

Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.

Original language	English (US)
Pages (from-to)	5-6
Number of pages	2
Journal	Cancer Cell
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.ccr.2009.12.032
State	Published - Jan 19 2010

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccr.2009.12.032

Cite this

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title = "A Tumor Suppressor SIRTainty",

abstract = "Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.",

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AB - Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.

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A Tumor Suppressor SIRTainty

Abstract

ASJC Scopus subject areas

UN SDGs

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