A Tumor Suppressor SIRTainty

Paul T. Schumacker*

*Corresponding author for this work

Research output: Contribution to journalShort survey

19 Scopus citations

Abstract

Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.

Original languageEnglish (US)
Pages (from-to)5-6
Number of pages2
JournalCancer Cell
Volume17
Issue number1
DOIs
StatePublished - Jan 19 2010

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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