A Tumor Suppressor SIRTainty

Paul T. Schumacker*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

20 Scopus citations

Abstract

Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.

Original languageEnglish (US)
Pages (from-to)5-6
Number of pages2
JournalCancer Cell
Volume17
Issue number1
DOIs
StatePublished - Jan 19 2010

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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