Abstract
Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.
Original language | English (US) |
---|---|
Pages (from-to) | 5-6 |
Number of pages | 2 |
Journal | Cancer Cell |
Volume | 17 |
Issue number | 1 |
DOIs | |
State | Published - Jan 19 2010 |
ASJC Scopus subject areas
- Oncology
- Cell Biology
- Cancer Research