A violaceous nodule in a lung-transplant patient

Emily Milford*, Caroline Winslow, Rebecca Danhof

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Posttransplantation lymphoproliferative disorder (PTLD) is a rare complication of solid organ or allogenic bone marrow transplantation. Cases localized to the skin are even rarer, with only around 100 cases recorded in the literature [2]. We present a case of 60 year-old-woman, a lung transplant recipient, who presented with an asymptomatic violaceous nodule on her left medial calf. Histopathology was consistent with PTLD of the B-cell subtype, EBV negative. This case is unique in that it was of the B cell subtype of cutaneous PTLD, which has been less commonly observed than the T cell subtype. In addition, the case was EBV negative, which is rare in B cell cutaneous PTLD. The patient was treated with rituximab 600 mg IV weekly for four weeks and cytomegalovirus immune globulin (Cytogam) 100 mg/kg once, with resolution of the nodule.

Original languageEnglish (US)
JournalDermatology online journal
Volume22
Issue number6
StatePublished - 2016
Externally publishedYes

Keywords

  • Cutaneous posttransplantation lymphoproliferative disorder
  • Posttransplantation lymphoproliferative disorder of B-cell origin
  • Skin cancer in immunosuppressed
  • Skin cancer in transplant recipients

ASJC Scopus subject areas

  • Dermatology

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