A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes

Urs Christen, Kurt H. Edelmann, Dorian B. McGavern, Tom Wolfe, Bryan Coon, Meghann K. Teague, Stephen D. Miller, Michael B A Oldstone, Matthias G. Von Herrath*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

We document here that infection of prediabetic mice with a virus expressing an H-2Kb-restricted mimic ligand to a self epitope present on β cells accelerates the development of autoimmune diabetes. Immunization with the mimic ligand expanded autoreactive T cell populations, which was followed by their trafficking to the islets, as visualized in situ by tetramer staining. In contrast, the mimic ligand did not generate sufficient autoreactive T cells in naive mice to initiate disease. Diabetes acceleration did not occur in H-2K b-deficient mice or in mice tolerized to the mimic ligand. Thus, arenavirus-expressed mimics of self antigens accelerate a previously established autoimmune process. Sequential heterologous viral infections might therefore act in concert to precipitate clinical autoimmune disease, even if single exposure to a viral mimic does not always cause sufficient tissue destruction.

Original languageEnglish (US)
Pages (from-to)1290-1298
Number of pages9
JournalJournal of Clinical Investigation
Volume114
Issue number9
DOIs
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes'. Together they form a unique fingerprint.

Cite this