A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery

Jihye Kim; Matthew I. Bury; Kyeongha Kwon; Jae Young Yoo; Nadia V. Halstead; Hee Sup Shin; Shupeng Li; Sang Min Won; Min Ho Seo; Yunyun Wu; Do Yun Park; Mitali Kini; Jean Won Kwak; Surabhi R. Madhvapathy; Joanna L. Ciatti; Jae Hee Lee; Suyeon Kim; Hanjun Ryu; Kento Yamagishi; Hong Joon Yoon; Sung Soo Kwak; Bosung Kim; Yonggang Huang; Lisa C. Halliday; Earl Y. Cheng; Arun K. Sharma; Guillermo A. Ameer; John A. Rogers

doi:10.1073/pnas.2400868121

A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery

Jihye Kim, Matthew I. Bury, Kyeongha Kwon, Jae Young Yoo, Nadia V. Halstead, Hee Sup Shin, Shupeng Li, Sang Min Won, Min Ho Seo, Yunyun Wu, Do Yun Park, Mitali Kini, Jean Won Kwak, Surabhi R. Madhvapathy, Joanna L. Ciatti, Jae Hee Lee, Suyeon Kim, Hanjun Ryu, Kento Yamagishi, Hong Joon YoonSung Soo Kwak, Bosung Kim, Yonggang Huang, Lisa C. Halliday, Earl Y. Cheng, Arun K. Sharma^*, Guillermo A. Ameer^*, John A. Rogers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients. Here, we introduce a fully bladder-implantable platform that allows for continuous, real-time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real-time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long-term postoperative bladder recovery monitoring.

Original language	English (US)
Article number	e2400868121
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	121
Issue number	14
DOIs	https://doi.org/10.1073/pnas.2400868121
State	Published - Apr 2 2024

Funding

Support of this work was provided in part by the NIH National Institute of Diabetes and Digestive and Kidney Diseases [NIDDK; R01DK109539 (A.K.S.)] and the National Institute of Biomedical Imaging and Bioengineering [NIBIB; R01EB026572 (G.A.A., A.K.S., and J.A.R.)]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. A.K.S. would like to acknowledge the Michelon Family and Legacy Healthcare for their generosity. K.K. acknowledges support from the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP; Ministry of Science, ICT & Future Planning; No. 2021R1F1A106387111, No. 2022R1C1C1010555, No. 2020R1A5A8018367, and BK21). M.-H.S. acknowledges support by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant number: HR20C0026). ACKNOWLEDGMENTS. Support of this work was provided in part by the NIH National Institute of Diabetes and Digestive and Kidney Diseases [NIDDK; R01DK109539 (A.K.S.)] and the National Institute of Biomedical Imaging and Bioengineering [NIBIB; R01EB026572 (G.A.A., A.K.S., and J.A.R.)]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. A.K.S. would like to acknowledge the Michelon Family and Legacy Healthcare for their generosity. K.K. acknowledges support from the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP; Ministry of Science,ICT& Future Planning; No.2021R1F1A106387111,No. 2022R1C1C1010555,No.2020R1A5A8018367,and BK21).M.-H.S.acknowledges support by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant number: HR20C0026).

Keywords

bioelectronics
bladder
regeneration
sensing
wireless

ASJC Scopus subject areas

General

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10.1073/pnas.2400868121

Cite this

Kim, J., Bury, M. I., Kwon, K., Yoo, J. Y., Halstead, N. V., Shin, H. S., Li, S., Won, S. M., Seo, M. H., Wu, Y., Park, D. Y., Kini, M., Kwak, J. W., Madhvapathy, S. R., Ciatti, J. L., Lee, J. H., Kim, S., Ryu, H., Yamagishi, K., ... Rogers, J. A. (2024). A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery. Proceedings of the National Academy of Sciences of the United States of America, 121(14), Article e2400868121. https://doi.org/10.1073/pnas.2400868121

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title = "A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery",

abstract = "Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients. Here, we introduce a fully bladder-implantable platform that allows for continuous, real-time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real-time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long-term postoperative bladder recovery monitoring.",

keywords = "bioelectronics, bladder, regeneration, sensing, wireless",

author = "Jihye Kim and Bury, {Matthew I.} and Kyeongha Kwon and Yoo, {Jae Young} and Halstead, {Nadia V.} and Shin, {Hee Sup} and Shupeng Li and Won, {Sang Min} and Seo, {Min Ho} and Yunyun Wu and Park, {Do Yun} and Mitali Kini and Kwak, {Jean Won} and Madhvapathy, {Surabhi R.} and Ciatti, {Joanna L.} and Lee, {Jae Hee} and Suyeon Kim and Hanjun Ryu and Kento Yamagishi and Yoon, {Hong Joon} and Kwak, {Sung Soo} and Bosung Kim and Yonggang Huang and Halliday, {Lisa C.} and Cheng, {Earl Y.} and Sharma, {Arun K.} and Ameer, {Guillermo A.} and Rogers, {John A.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2024 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).",

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Kim, J, Bury, MI, Kwon, K, Yoo, JY, Halstead, NV, Shin, HS, Li, S, Won, SM, Seo, MH, Wu, Y, Park, DY, Kini, M, Kwak, JW, Madhvapathy, SR, Ciatti, JL, Lee, JH, Kim, S, Ryu, H, Yamagishi, K, Yoon, HJ, Kwak, SS, Kim, B, Huang, Y, Halliday, LC, Cheng, EY , Sharma, AK , Ameer, GA & Rogers, JA 2024, 'A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery', Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 14, e2400868121. https://doi.org/10.1073/pnas.2400868121

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AU - Kim, Jihye

AU - Bury, Matthew I.

AU - Kwon, Kyeongha

AU - Yoo, Jae Young

AU - Halstead, Nadia V.

AU - Shin, Hee Sup

AU - Li, Shupeng

AU - Won, Sang Min

AU - Seo, Min Ho

AU - Wu, Yunyun

AU - Park, Do Yun

AU - Kini, Mitali

AU - Kwak, Jean Won

AU - Madhvapathy, Surabhi R.

AU - Ciatti, Joanna L.

AU - Lee, Jae Hee

AU - Kim, Suyeon

AU - Ryu, Hanjun

AU - Yamagishi, Kento

AU - Yoon, Hong Joon

AU - Kwak, Sung Soo

AU - Kim, Bosung

AU - Huang, Yonggang

AU - Halliday, Lisa C.

AU - Cheng, Earl Y.

AU - Sharma, Arun K.

AU - Ameer, Guillermo A.

AU - Rogers, John A.

PY - 2024/4/2

Y1 - 2024/4/2

N2 - Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients. Here, we introduce a fully bladder-implantable platform that allows for continuous, real-time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real-time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long-term postoperative bladder recovery monitoring.

AB - Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients. Here, we introduce a fully bladder-implantable platform that allows for continuous, real-time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real-time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long-term postoperative bladder recovery monitoring.

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A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery

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