A wireless, skin-interfaced biosensor for cerebral hemodynamic monitoring in pediatric care

Alina Y. Rwei*, Wei Lu, Changsheng Wu, Kelia Human, Emily Suen, Daniel Franklin, Monica Fabiani, Gabriele Gratton, Zhaoqian Xie, Yujun Deng, Sung Soo Kwak, Lizhu Li, Carol Gu, Alanna Liu, Casey M. Rand, Tracey M. Stewart, Yonggang Huang, Debra E. Weese-Mayer, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The standard of clinical care in many pediatric and neonatal neurocritical care units involves continuous monitoring of cerebral hemodynamics using hard-wired devices that physically adhere to the skin and connect to base stations that commonly mount on an adjacent wall or stand. Risks of iatrogenic skin injuries associated with adhesives that bond such systems to the skin and entanglements of the patients and/or the healthcare professionals with the wires can impede clinical procedures and natural movements that are critical to the care, development, and recovery of pediatric patients. This paper presents a wireless, miniaturized, and mechanically soft, flexible device that supports measurements quantitatively comparable to existing clinical standards. The system features a multiphotodiode array and pair of light-emitting diodes for simultaneous monitoring of systemic and cerebral hemodynamics, with ability to measure cerebral oxygenation, heart rate, peripheral oxygenation, and potentially cerebral pulse pressure and vascular tone, through the utilization of multiwavelength reflectance-mode photoplethysmography and functional near-infrared spectroscopy. Monte Carlo optical simulations define the tissue-probing depths for source-detector distances and operating wavelengths of these systems using magnetic resonance images of the head of a representative pediatric patient to define the relevant geometries. Clinical studies on pediatric subjects with and without congenital central hypoventilation syndrome validate the feasibility for using this system in operating hospitals and define its advantages relative to established technologies. This platform has the potential to substantially enhance the quality of pediatric care across a wide range of conditions and use scenarios, not only in advanced hospital settings but also in clinics of lower- and middle-income countries.

Original languageEnglish (US)
Pages (from-to)31674-31684
Number of pages11
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number50
StatePublished - Dec 15 2020


  • Bioelectronics
  • Cerebral hemodynamics
  • Near-Infrared spectroscopy
  • Wearable electronics

ASJC Scopus subject areas

  • General


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