A young woman with blurred vision and distal paresthesias

Nathan H. Kung, Nancy L. Bartlett, Nabeel R. Yaseen, Gregory P. Van Stavern, Robert C. Bucelli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A 29-year-old woman presented with blurred vision and distal paresthesias. Her initial evaluation revealed severe bilateral optic disc edema with distal lower-extremity sensory and motor deficits and electrodiagnostic evidence of a length-dependent mixed demyelinating and axonal polyneuropathy. The results of routine diagnostic testing, including laboratory tests, magnetic resonance imaging, and lumbar puncture, were nondiagnostic. A targeted biopsy was ultimately required for diagnosis. In this article, we discuss the differential diagnosis and outline the clinical evaluation indicated for a patient presenting with demyelinating polyneuropathy and concurrent papilledema.

Original languageEnglish (US)
Pages (from-to)1519-1526
Number of pages8
JournalJAMA Neurology
Issue number12
StatePublished - Dec 2015

ASJC Scopus subject areas

  • Clinical Neurology


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