AAAPT Diagnostic Criteria for Acute Neuropathic Pain

Tina L. Doshi*, Robert H. Dworkin, Rosemary C. Polomano, Daniel B. Carr, Robert R. Edwards, Nanna B. Finnerup, Roy L. Freeman, Judith A. Paice, Steven J. Weisman, Srinivasa N. Raja

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: Acute neuropathic pain is a significant diagnostic challenge, and it is closely related to our understanding of both acute pain and neuropathic pain. Diagnostic criteria for acute neuropathic pain should reflect our mechanistic understanding and provide a framework for research on and treatment of these complex pain conditions. Methods: The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the U.S. Food and Drug Administration (FDA), the American Pain Society (APS), and the American Academy of Pain Medicine (AAPM) collaborated to develop the ACTTION-APS-AAPM Pain Taxonomy (AAAPT) for acute pain. A working group of experts in research and clinical management of neuropathic pain was convened. Group members used literature review and expert opinion to develop diagnostic criteria for acute neuropathic pain, as well as three specific examples of acute neuropathic pain conditions, using the five dimensions of the AAAPT classification of acute pain. Results: AAAPT diagnostic criteria for acute neuropathic pain are presented. Application of these criteria to three specific conditions (pain related to herpes zoster, chemotherapy, and limb amputation) illustrates the spectrum of acute neuropathic pain and highlights unique features of each condition. Conclusions: The proposed AAAPT diagnostic criteria for acute neuropathic pain can be applied to various acute neuropathic pain conditions. Both the general and condition-specific criteria may guide future research, assessment, and management of acute neuropathic pain.

Original languageEnglish (US)
Pages (from-to)616-636
Number of pages21
JournalPain Medicine (United States)
Issue number3
StatePublished - Mar 1 2021

ASJC Scopus subject areas

  • General Medicine


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