AAN position statement: Ethical issues in clinical research in neurology

Benjamin Tolchin*, Robin Conwit, Leon G. Epstein, James A. Russell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


This update to the American Academy of Neurology's 1998 position statement endeavors to provide guidance for the consistent ethical conduct and review of neurologic research involving human participants. It does so by outlining a widely used ethical framework of 7 principles derived from the foundational documents of modern bioethics, including the Nuremberg Code, the World Medical Association's Declaration of Helsinki, the Belmont Report, and the US Department of Health and Human Service's Common Rule. The position statement then applies this principle-based framework to analyze and produce recommendations for the management of common and important ethical issues encountered in neurologic clinical research. These include institutional review board oversight, equitable research participant inclusion, cognitive impairment in research participants, international studies, the replication crisis, and genetic testing and modification.

Original languageEnglish (US)
Pages (from-to)661-669
Number of pages9
Issue number15
StatePublished - Apr 14 2020

ASJC Scopus subject areas

  • Clinical Neurology

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