Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons

Adriana Ferreira, Kenneth S. Kosik, Paul Greengard, Hui Quan Han*

*Corresponding author for this work

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

Synapsin I and synapsin II are neuron-specific phosphoproteins that have a role in the regulation of neurotransmitter release and in the formation of nerve terminals. After depletion of synapsin II by antisense oligonucleotides, rat hippocampal neurons in culture were unable to consolidate their minor processes and did not elongate axons. These aberrant morphological changes were accompanied by an abnormal distribution of intracellular filamentous actin (F-actin). In addition, synapsin II suppression resulted in a selective decrease in the amounts of several synaptic vesicle-associated proteins. These data suggest that synapsin II participates in cytoskeletal organization during the early stages of nerve cell development.

Original languageEnglish (US)
Pages (from-to)977-979
Number of pages3
JournalScience
Volume264
Issue number5161
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • General

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