Abnormal kalirin signaling in neuropsychiatric disorders

Christine Remmers, Robert A. Sweet, Peter Penzes*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Changes in dendritic spines structure and function play a critical role in a number of physiological processes, including synaptic transmission and plasticity, and are intimately linked to cognitive function. Alterations in dendritic spine morphogenesis occur in a number of neuropsychiatric disorders and likely underlie the cognitive and behavioral changes associated with these disorders. The neuronal guanine nucleotide exchange factor (GEF) kalirin is emerging as a key regulator of structural and functional plasticity at dendritic spines. Moreover, a series of recent studies have genetically and functionally linked kalirin signaling to several disorders, including schizophrenia and Alzheimer's disease. Kalirin signaling may thus represent a disease mechanism and provide a novel therapeutic target. This article is part of a special Issue entitled 'Dendrites and Disease'.

Original languageEnglish (US)
Pages (from-to)29-38
Number of pages10
JournalBrain Research Bulletin
Volume103
DOIs
StatePublished - Apr 2014

Keywords

  • Alzheimer's disease
  • Genetic
  • Glutamatergic
  • Mental disorder
  • Postmortem
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

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