Abnormal red blood cell ion transport and hypertension: The people’s gas company study

Maurizio Trevisan, David Ostrow, Richard Cooper*, Kiang Liu, Stephen Sparks, Anna Okonek, Elizabeth Stevens, John Marquardt, Jeremiah Stamler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


A population-based survey of 134 white men, recruited from the Chicago People’s Gas Company labor force, was carried out to examine the association between sodium-lithium (Na-Li) countertransport and hypertension. Of the 134 participants in this industry-sponsored periodic health examination, 64 were normotensive and 70 were either taking antihypertensive medications or had a systolic pressure ≥ 140 or a diastolic pressure ≥ 90 mm Hg. The hypertensives were older and more overweight. Countertransport was significantly higher in hypertensives than in normotensives. Among the three subgroups of hypertensives - untreated borderline (140/90 to 160/95 mm Hg), untreated definite (over 160/95 mm Hg), and treated - an increase in countertransport was consistently observed, significant for the latter two groups. The relationship between countertransport and hypertension was independent of overweight, with countertransport being significantly related to both blood pressure and overweight. Altered ion transport may play an important role in the etiology and/or pathophysiology of hypertension.

Original languageEnglish (US)
Pages (from-to)363-367
Number of pages5
Issue number3
StatePublished - 1983


  • Blood pressure
  • Countertransport
  • Sodium metabolism

ASJC Scopus subject areas

  • Internal Medicine


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