Abnormalities in hippocampal functioning with persistent pain

Amelia A. Mutso, Daniel Radzicki, Marwan N Baliki, Lejian Huang, Ghazal Banisadr, Maria V. Centeno, Jelena Radulovic, Marco Martina, Richard J Miller, Apkar Apkarian*

*Corresponding author for this work

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Chronic pain patients exhibit increased anxiety, depression, and deficits in learning and memory. Yet how persistent pain affects the key brain area regulating these behaviors, the hippocampus, has remained minimally explored. In this study we investigated the impact of spared nerve injury (SNI) neuropathic pain in mice on hippocampal-dependent behavior and underlying cellular and molecular changes. In parallel, we measured the hippocampal volume of three groups of chronic pain patients. We found that SNI animals were unable to extinguish contextual fear and showed increased anxiety-like behavior. Additionally, SNI mice compared with Sham animals exhibited hippocampal (1) reduced extracellular signal-regulated kinase expression and phosphorylation, (2) decreased neurogenesis, and (3) altered short-term synaptic plasticity. To relate the observed hippocampal abnormalities with human chronic pain, we measured the volume of human hippocampus in chronic back pain (CBP), complex regional pain syndrome (CRPS), and osteoarthritis patients (OA). Compared with controls, CBP and CRPS, but not OA, had significantly less bilateral hippocampal volume. These results indicate that hippocampus-mediated behavior, synaptic plasticity, and neurogenesis are abnormal in neuropathic rodents. The changes may be related to the reduction in hippocampal volume we see in chronic pain patients, and these abnormalities may underlie learning and emotional deficits commonly observed in such patients.

Original languageEnglish (US)
Pages (from-to)5747-5756
Number of pages10
JournalJournal of Neuroscience
Volume32
Issue number17
DOIs
StatePublished - Apr 25 2012

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Chronic Pain
Pain
Complex Regional Pain Syndromes
Hippocampus
Neuronal Plasticity
Neurogenesis
Back Pain
Osteoarthritis
Wounds and Injuries
Anxiety
Learning
Mitogen-Activated Protein Kinase 3
Neuralgia
Fear
Rodentia
Phosphorylation
Depression
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Abnormalities in hippocampal functioning with persistent pain",
abstract = "Chronic pain patients exhibit increased anxiety, depression, and deficits in learning and memory. Yet how persistent pain affects the key brain area regulating these behaviors, the hippocampus, has remained minimally explored. In this study we investigated the impact of spared nerve injury (SNI) neuropathic pain in mice on hippocampal-dependent behavior and underlying cellular and molecular changes. In parallel, we measured the hippocampal volume of three groups of chronic pain patients. We found that SNI animals were unable to extinguish contextual fear and showed increased anxiety-like behavior. Additionally, SNI mice compared with Sham animals exhibited hippocampal (1) reduced extracellular signal-regulated kinase expression and phosphorylation, (2) decreased neurogenesis, and (3) altered short-term synaptic plasticity. To relate the observed hippocampal abnormalities with human chronic pain, we measured the volume of human hippocampus in chronic back pain (CBP), complex regional pain syndrome (CRPS), and osteoarthritis patients (OA). Compared with controls, CBP and CRPS, but not OA, had significantly less bilateral hippocampal volume. These results indicate that hippocampus-mediated behavior, synaptic plasticity, and neurogenesis are abnormal in neuropathic rodents. The changes may be related to the reduction in hippocampal volume we see in chronic pain patients, and these abnormalities may underlie learning and emotional deficits commonly observed in such patients.",
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Abnormalities in hippocampal functioning with persistent pain. / Mutso, Amelia A.; Radzicki, Daniel; Baliki, Marwan N; Huang, Lejian; Banisadr, Ghazal; Centeno, Maria V.; Radulovic, Jelena; Martina, Marco; Miller, Richard J; Apkarian, Apkar.

In: Journal of Neuroscience, Vol. 32, No. 17, 25.04.2012, p. 5747-5756.

Research output: Contribution to journalArticle

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AU - Radzicki, Daniel

AU - Baliki, Marwan N

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AU - Radulovic, Jelena

AU - Martina, Marco

AU - Miller, Richard J

AU - Apkarian, Apkar

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