Abnormalities in Resting-State Functional Connectivity in Early Human Immunodeficiency Virus Infection

Xue Wang, Paul Foryt, Renee Ochs, Jae Hoon Chung, Ying wu, Todd Parrish, Ann B. Ragin*

*Corresponding author for this work

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Limited information is available concerning changes that occur in the brain early in human immunodeficiency virus (HIV) infection. This investigation evaluated resting-state functional connectivity, which is based on correlations of spontaneous blood oxygen level-dependent functional magnetic resonance imaging (fMRI) oscillations between brain regions, in 15 subjects within the first year of HIV infection and in 15 age-matched controls. Resting-state fMRI data for each session were concatenated in time across subjects to create a single 4D dataset and decomposed into 36 independent component analysis (ICA) using Multivariate Exploratory Linear Optimized Decomposition into Independent Components. ICA components were back-reconstructed for each subject's 4D data to estimate subject-specific spatial maps using the dual-regression technique. Comparison of spatial maps between HIV and controls revealed significant differences in the lateral occipital cortex (LOC) network. Reduced coactivation in left inferior parietal cortex within the LOC network was identified in the HIV subjects. Connectivity strength within this region correlated with performance on tasks involving visual-motor coordination (Grooved Pegboard and Rey Figure Copy) in the HIV group. The findings indicate prominent changes in resting-state functional connectivity of visual networks early in HIV infection. This network may sustain injury in association with the intense viremia and brain viral invasion before immune defenses can contain viral replication. Resting-state functional connectivity may have utility as a noninvasive neuroimaging biomarker for central nervous system impairment in early HIV infection.

Original languageEnglish
Pages (from-to)207-217
Number of pages11
JournalBrain Connectivity
Volume1
Issue number3
DOIs
StatePublished - Sep 1 2011

Keywords

  • early HIV infection
  • lateral occipital cortex network
  • resting-state functional connectivity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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