Abstract
In this issue of Blood, Peffault de Latour et al demonstrate that interleukin-17 (IL-17)-producing Th17 T cells are increased in the peripheral blood and bone marrow of patients with aplastic anemia, compared with healthy controls. They also provide evidence that IL-17 contributes to the severity of marrow failure at an early stage. This work advances our overall understanding of the mechanisms of immune-mediated hematopoietic suppression and may ultimately have important clinical implications for the treatment of aplastic anemia.
Original language | English (US) |
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Pages (from-to) | 4039-4040 |
Number of pages | 2 |
Journal | Blood |
Volume | 116 |
Issue number | 20 |
DOIs |
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State | Published - Nov 18 2010 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology