Abnormalities in Th17 T cells in aplastic anemia

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7 Scopus citations


In this issue of Blood, Peffault de Latour et al demonstrate that interleukin-17 (IL-17)-producing Th17 T cells are increased in the peripheral blood and bone marrow of patients with aplastic anemia, compared with healthy controls. They also provide evidence that IL-17 contributes to the severity of marrow failure at an early stage. This work advances our overall understanding of the mechanisms of immune-mediated hematopoietic suppression and may ultimately have important clinical implications for the treatment of aplastic anemia.

Original languageEnglish (US)
Pages (from-to)4039-4040
Number of pages2
Issue number20
StatePublished - Nov 18 2010

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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