In summary, these data confirm the presence of abnormal skeletal muscle metabolic function in patients with chronic heart failure. These changes are independent of patient compliance and central hemodynamic response to conventional exercise, and may explain, in part, the marked decrease in exercise tolerance often observed in patients with chronic severe heart failure. The etiology of these abnormalities of metabolic function and nutritive flow remains uncertain. TNS may prove useful in furthur elucidation of the peripheral metabolic consequences of chronic heart failure.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine