Absence of hyperinsulinemia in isoimmunized fetuses treated with intravascular transfusion

Michael L. Socol; Sharon L. Dooley; Judith A. Ney; John P. Minogue; Dietra D. Millard; Edward S. Ogata

doi:10.1016/0002-9378(91)90025-M

Absence of hyperinsulinemia in isoimmunized fetuses treated with intravascular transfusion

Michael L. Socol^*, Sharon L. Dooley, Judith A. Ney, John P. Minogue, Dietra D. Millard, Edward S. Ogata

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We serially sampled blood from fetuses of five severely isoimmunized pregnancies at the time of each intrauterine intravascular transfusion and at birth. We were unable to demonstrate either an elevation in the plasma insulin/glucose ratio or a relationship between the insulin/glucose ratio and hemoglobin concentration at any time period. Plasma total glutathione concentration, however, decreased dramatically from the initial to the second transfusion (323 ± 114 to 43 ± 9 ng/ml; t = -5.06, p < 0.01). We speculate that intrauterine transfusion may modify or prevent the previously reported fetal pancreatic β-cell hyperplasia and hyperinsulinemia associated with isoimmunization by decreasing red blood cell hemolysis and thereby circulating glutathione.

Original language	English (US)
Pages (from-to)	1737-1740
Number of pages	4
Journal	American journal of obstetrics and gynecology
Volume	165
Issue number	6 PART 1
DOIs	https://doi.org/10.1016/0002-9378(91)90025-M
State	Published - Dec 1991

Keywords

Fetal hyperinsulinemia
intrauterine transfusion
isoimmunization

ASJC Scopus subject areas

Obstetrics and Gynecology

Access to Document

10.1016/0002-9378(91)90025-M

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title = "Absence of hyperinsulinemia in isoimmunized fetuses treated with intravascular transfusion",

abstract = "We serially sampled blood from fetuses of five severely isoimmunized pregnancies at the time of each intrauterine intravascular transfusion and at birth. We were unable to demonstrate either an elevation in the plasma insulin/glucose ratio or a relationship between the insulin/glucose ratio and hemoglobin concentration at any time period. Plasma total glutathione concentration, however, decreased dramatically from the initial to the second transfusion (323 ± 114 to 43 ± 9 ng/ml; t = -5.06, p < 0.01). We speculate that intrauterine transfusion may modify or prevent the previously reported fetal pancreatic β-cell hyperplasia and hyperinsulinemia associated with isoimmunization by decreasing red blood cell hemolysis and thereby circulating glutathione.",

keywords = "Fetal hyperinsulinemia, intrauterine transfusion, isoimmunization",

author = "Socol, {Michael L.} and Dooley, {Sharon L.} and Ney, {Judith A.} and Minogue, {John P.} and Millard, {Dietra D.} and Ogata, {Edward S.}",

year = "1991",

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AU - Socol, Michael L.

AU - Dooley, Sharon L.

AU - Ney, Judith A.

AU - Minogue, John P.

AU - Millard, Dietra D.

AU - Ogata, Edward S.

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N2 - We serially sampled blood from fetuses of five severely isoimmunized pregnancies at the time of each intrauterine intravascular transfusion and at birth. We were unable to demonstrate either an elevation in the plasma insulin/glucose ratio or a relationship between the insulin/glucose ratio and hemoglobin concentration at any time period. Plasma total glutathione concentration, however, decreased dramatically from the initial to the second transfusion (323 ± 114 to 43 ± 9 ng/ml; t = -5.06, p < 0.01). We speculate that intrauterine transfusion may modify or prevent the previously reported fetal pancreatic β-cell hyperplasia and hyperinsulinemia associated with isoimmunization by decreasing red blood cell hemolysis and thereby circulating glutathione.

AB - We serially sampled blood from fetuses of five severely isoimmunized pregnancies at the time of each intrauterine intravascular transfusion and at birth. We were unable to demonstrate either an elevation in the plasma insulin/glucose ratio or a relationship between the insulin/glucose ratio and hemoglobin concentration at any time period. Plasma total glutathione concentration, however, decreased dramatically from the initial to the second transfusion (323 ± 114 to 43 ± 9 ng/ml; t = -5.06, p < 0.01). We speculate that intrauterine transfusion may modify or prevent the previously reported fetal pancreatic β-cell hyperplasia and hyperinsulinemia associated with isoimmunization by decreasing red blood cell hemolysis and thereby circulating glutathione.

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