Absence of progesterone receptors in a failed case of fertility-sparing treatment in early endometrial cancer: A case report

Anna V. Hoekstra, J. Julie Kim, Pacita Keh, Julian C. Schink

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

BACKGROUND: Fertility-sparing treatment may be offered as an alternative to standard surgical management of early-stage, well-differentiated endometrial cancer in young women. Immunostaining for progesterone receptor (PR) status is not currently part of the standard workup before treatment recommendations are made. CASE: We describe a 29-year-old woman who used oral contraceptive pills on a long-term basis in whom early-stage, well-differentiated endometrial cancer was diagnosed. Progestin therapy failed and the tumor was subsequently found to be PR negative. CONCLUSION: Combination oral contraceptive pills may stimulate clonal expansion of endometrial cells that lack PR, leading to endometrial adenocarcinoma unresponsive to progestin therapy. Consideration should be given to PR immunostaining for confirmation of the receptor status and evaluation of appropriate management options when counseling patients about fertility-sparing therapy.

Original languageEnglish (US)
Pages (from-to)869-873
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume53
Issue number11
StatePublished - Nov 2008

Keywords

  • Endometrial neoplasms
  • Fertility
  • Progesterone receptors
  • Progestins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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