Absence of sperm-specific lactate dehydrogenase-x in patients with testis cancer

N. J. Vogelzang; P. H. Lange; E. Goldberg

Absence of sperm-specific lactate dehydrogenase-x in patients with testis cancer

N. J. Vogelzang, P. H. Lange, E. Goldberg

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

LDH-x is a unique form of lactate dehydrogenase found in germinal epithelium during spermatogenesis. 53 patients with germ cell tumors were screened for the presence of LDH-x in the serum. No patient had detectable levels of the enzyme. 31 of the patients had elevated total serum LDH levels, and the isozyme fraction type 1 and/or type 2 was responsible for the elevation in all cases. LDH is a useful marker in germ cell tumors, but LDH-x is not the responsible isozyme.

Original language	English (US)
Pages (from-to)	269-272
Number of pages	4
Journal	Oncodevelopmental Biology and Medicine
Volume	3
Issue number	4
State	Published - Dec 1 1982

ASJC Scopus subject areas

Medicine(all)

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Cite this

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abstract = "LDH-x is a unique form of lactate dehydrogenase found in germinal epithelium during spermatogenesis. 53 patients with germ cell tumors were screened for the presence of LDH-x in the serum. No patient had detectable levels of the enzyme. 31 of the patients had elevated total serum LDH levels, and the isozyme fraction type 1 and/or type 2 was responsible for the elevation in all cases. LDH is a useful marker in germ cell tumors, but LDH-x is not the responsible isozyme.",

author = "Vogelzang, {N. J.} and Lange, {P. H.} and E. Goldberg",

year = "1982",

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AU - Goldberg, E.

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N2 - LDH-x is a unique form of lactate dehydrogenase found in germinal epithelium during spermatogenesis. 53 patients with germ cell tumors were screened for the presence of LDH-x in the serum. No patient had detectable levels of the enzyme. 31 of the patients had elevated total serum LDH levels, and the isozyme fraction type 1 and/or type 2 was responsible for the elevation in all cases. LDH is a useful marker in germ cell tumors, but LDH-x is not the responsible isozyme.

AB - LDH-x is a unique form of lactate dehydrogenase found in germinal epithelium during spermatogenesis. 53 patients with germ cell tumors were screened for the presence of LDH-x in the serum. No patient had detectable levels of the enzyme. 31 of the patients had elevated total serum LDH levels, and the isozyme fraction type 1 and/or type 2 was responsible for the elevation in all cases. LDH is a useful marker in germ cell tumors, but LDH-x is not the responsible isozyme.

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Absence of sperm-specific lactate dehydrogenase-x in patients with testis cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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