Absolute barrier isolation and antibiotics in the treatment of experimental burn wound sepsis

Francis C. Nance; Victor Lewis; George H. Bornside

doi:10.1016/0022-4804(70)90007-7

Absolute barrier isolation and antibiotics in the treatment of experimental burn wound sepsis

Francis C. Nance^*, Victor Lewis, George H. Bornside

^*Corresponding author for this work

Surgery, Plastic Surgery Division

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

1. 1. A model for studying the effect of absolute barrier isolation on mortality from burn wound sepsis is described. 2. 2. Systemic polymyxin alone did not increase survival in this model. 3. 3. Topical mafenide with or without systemic polymyxin markedly improved survival from experimental burn wound sepsis. 4. 4. The mortality of animals treated with systemic and oral polymyxin, topical mafenide, and absolute barrier (germfree) isolation was the same as the mortality of similarly treated animals without isolation. 5. 5. In this model, absolute barrier isolation was of no value in the treatment of experimentally contaminated burn wounds.

Original language	English (US)
Pages (from-to)	33-39
Number of pages	7
Journal	Journal of Surgical Research
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/0022-4804(70)90007-7
State	Published - Jan 1970

Funding

Supported by grants from The Edward G. Schleider Educational Foundation, New Orleans, Louisiana, Cancer Association Research, New Orleans, Louisiana, and by a general research grant, NIH FR 5376. Submitted for publication July 1, 1969.

ASJC Scopus subject areas

Surgery

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10.1016/0022-4804(70)90007-7

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title = "Absolute barrier isolation and antibiotics in the treatment of experimental burn wound sepsis",

abstract = "1. 1. A model for studying the effect of absolute barrier isolation on mortality from burn wound sepsis is described. 2. 2. Systemic polymyxin alone did not increase survival in this model. 3. 3. Topical mafenide with or without systemic polymyxin markedly improved survival from experimental burn wound sepsis. 4. 4. The mortality of animals treated with systemic and oral polymyxin, topical mafenide, and absolute barrier (germfree) isolation was the same as the mortality of similarly treated animals without isolation. 5. 5. In this model, absolute barrier isolation was of no value in the treatment of experimentally contaminated burn wounds.",

author = "Nance, {Francis C.} and Victor Lewis and Bornside, {George H.}",

note = "Funding Information: Supported by grants from The Edward G. Schleider Educational Foundation, New Orleans, Louisiana, Cancer Association Research, New Orleans, Louisiana, and by a general research grant, NIH FR 5376. Submitted for publication July 1, 1969.",

year = "1970",

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doi = "10.1016/0022-4804(70)90007-7",

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T1 - Absolute barrier isolation and antibiotics in the treatment of experimental burn wound sepsis

AU - Nance, Francis C.

AU - Lewis, Victor

AU - Bornside, George H.

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PY - 1970/1

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N2 - 1. 1. A model for studying the effect of absolute barrier isolation on mortality from burn wound sepsis is described. 2. 2. Systemic polymyxin alone did not increase survival in this model. 3. 3. Topical mafenide with or without systemic polymyxin markedly improved survival from experimental burn wound sepsis. 4. 4. The mortality of animals treated with systemic and oral polymyxin, topical mafenide, and absolute barrier (germfree) isolation was the same as the mortality of similarly treated animals without isolation. 5. 5. In this model, absolute barrier isolation was of no value in the treatment of experimentally contaminated burn wounds.

AB - 1. 1. A model for studying the effect of absolute barrier isolation on mortality from burn wound sepsis is described. 2. 2. Systemic polymyxin alone did not increase survival in this model. 3. 3. Topical mafenide with or without systemic polymyxin markedly improved survival from experimental burn wound sepsis. 4. 4. The mortality of animals treated with systemic and oral polymyxin, topical mafenide, and absolute barrier (germfree) isolation was the same as the mortality of similarly treated animals without isolation. 5. 5. In this model, absolute barrier isolation was of no value in the treatment of experimentally contaminated burn wounds.

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Absolute barrier isolation and antibiotics in the treatment of experimental burn wound sepsis

Abstract

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