Absolute neutrophil count as a diagnostic guide for the use of MRI in the workup of suspected appendicitis in children

Kristine S. Corkum, Tolulope A. Oyetunji, Julia E Grabowski, Cynthia K Rigsby, Timothy B Lautz*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Purpose: To assess the additive value of magnetic resonance imaging (MRI) in the setting of an equivocal US (Eq-US) with or without an elevated absolute neutrophil count (ANC). Methods: Single-institution, retrospective review of children ages 5–18 years who presented to the ER with suspected appendicitis from 9/2015 to 8/2016. US, ANC, and MRI results were reviewed. Imaging was identified as positive/suspicious, normal, or equivocal and ANC < 8000/mm3 was defined as normal. Results: 738 patients with a median age of 11 years (IQR 8–14) met inclusion criteria. US was equivocal in 61.4%. Among 304 (67.1%) patients with an Eq-US and normal ANC, only 5 (1.6%) had acute appendicitis. In contrast, 28 of 149 patients (18.8%) with Eq-US and elevated ANC had appendicitis. MRI was performed in 125 patients with Eq-US and was positive/suspicious in 2.9% (2/69) with normal ANC and 25.0% (14/56) with elevated ANC. MRI had 94.7% sensitivity and 100% specificity for acute appendicitis in patients with an Eq-US. Conclusions: MRI has high sensitivity and specificity for diagnosing acute appendicitis in children. Patients with Eq-US plus a normal ANC have a very low likelihood of appendicitis and do not typically require further imaging. MRI may have utility for children with Eq-US and elevated ANC. Level of Evidence: Level III.

Original languageEnglish (US)
Pages (from-to)1359-1364
Number of pages6
JournalJournal of pediatric surgery
Volume54
Issue number7
DOIs
StatePublished - Jul 1 2019

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Appendicitis
Neutrophils
Magnetic Resonance Imaging
Sensitivity and Specificity

Keywords

  • Absolute neutrophil count
  • Appendicitis
  • Children
  • Equivocal ultrasound
  • MRI

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

@article{da3432d52a2a43c79ff0445566421542,
title = "Absolute neutrophil count as a diagnostic guide for the use of MRI in the workup of suspected appendicitis in children",
abstract = "Background/Purpose: To assess the additive value of magnetic resonance imaging (MRI) in the setting of an equivocal US (Eq-US) with or without an elevated absolute neutrophil count (ANC). Methods: Single-institution, retrospective review of children ages 5–18 years who presented to the ER with suspected appendicitis from 9/2015 to 8/2016. US, ANC, and MRI results were reviewed. Imaging was identified as positive/suspicious, normal, or equivocal and ANC < 8000/mm3 was defined as normal. Results: 738 patients with a median age of 11 years (IQR 8–14) met inclusion criteria. US was equivocal in 61.4{\%}. Among 304 (67.1{\%}) patients with an Eq-US and normal ANC, only 5 (1.6{\%}) had acute appendicitis. In contrast, 28 of 149 patients (18.8{\%}) with Eq-US and elevated ANC had appendicitis. MRI was performed in 125 patients with Eq-US and was positive/suspicious in 2.9{\%} (2/69) with normal ANC and 25.0{\%} (14/56) with elevated ANC. MRI had 94.7{\%} sensitivity and 100{\%} specificity for acute appendicitis in patients with an Eq-US. Conclusions: MRI has high sensitivity and specificity for diagnosing acute appendicitis in children. Patients with Eq-US plus a normal ANC have a very low likelihood of appendicitis and do not typically require further imaging. MRI may have utility for children with Eq-US and elevated ANC. Level of Evidence: Level III.",
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Absolute neutrophil count as a diagnostic guide for the use of MRI in the workup of suspected appendicitis in children. / Corkum, Kristine S.; Oyetunji, Tolulope A.; Grabowski, Julia E; Rigsby, Cynthia K; Lautz, Timothy B.

In: Journal of pediatric surgery, Vol. 54, No. 7, 01.07.2019, p. 1359-1364.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Absolute neutrophil count as a diagnostic guide for the use of MRI in the workup of suspected appendicitis in children

AU - Corkum, Kristine S.

AU - Oyetunji, Tolulope A.

AU - Grabowski, Julia E

AU - Rigsby, Cynthia K

AU - Lautz, Timothy B

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background/Purpose: To assess the additive value of magnetic resonance imaging (MRI) in the setting of an equivocal US (Eq-US) with or without an elevated absolute neutrophil count (ANC). Methods: Single-institution, retrospective review of children ages 5–18 years who presented to the ER with suspected appendicitis from 9/2015 to 8/2016. US, ANC, and MRI results were reviewed. Imaging was identified as positive/suspicious, normal, or equivocal and ANC < 8000/mm3 was defined as normal. Results: 738 patients with a median age of 11 years (IQR 8–14) met inclusion criteria. US was equivocal in 61.4%. Among 304 (67.1%) patients with an Eq-US and normal ANC, only 5 (1.6%) had acute appendicitis. In contrast, 28 of 149 patients (18.8%) with Eq-US and elevated ANC had appendicitis. MRI was performed in 125 patients with Eq-US and was positive/suspicious in 2.9% (2/69) with normal ANC and 25.0% (14/56) with elevated ANC. MRI had 94.7% sensitivity and 100% specificity for acute appendicitis in patients with an Eq-US. Conclusions: MRI has high sensitivity and specificity for diagnosing acute appendicitis in children. Patients with Eq-US plus a normal ANC have a very low likelihood of appendicitis and do not typically require further imaging. MRI may have utility for children with Eq-US and elevated ANC. Level of Evidence: Level III.

AB - Background/Purpose: To assess the additive value of magnetic resonance imaging (MRI) in the setting of an equivocal US (Eq-US) with or without an elevated absolute neutrophil count (ANC). Methods: Single-institution, retrospective review of children ages 5–18 years who presented to the ER with suspected appendicitis from 9/2015 to 8/2016. US, ANC, and MRI results were reviewed. Imaging was identified as positive/suspicious, normal, or equivocal and ANC < 8000/mm3 was defined as normal. Results: 738 patients with a median age of 11 years (IQR 8–14) met inclusion criteria. US was equivocal in 61.4%. Among 304 (67.1%) patients with an Eq-US and normal ANC, only 5 (1.6%) had acute appendicitis. In contrast, 28 of 149 patients (18.8%) with Eq-US and elevated ANC had appendicitis. MRI was performed in 125 patients with Eq-US and was positive/suspicious in 2.9% (2/69) with normal ANC and 25.0% (14/56) with elevated ANC. MRI had 94.7% sensitivity and 100% specificity for acute appendicitis in patients with an Eq-US. Conclusions: MRI has high sensitivity and specificity for diagnosing acute appendicitis in children. Patients with Eq-US plus a normal ANC have a very low likelihood of appendicitis and do not typically require further imaging. MRI may have utility for children with Eq-US and elevated ANC. Level of Evidence: Level III.

KW - Absolute neutrophil count

KW - Appendicitis

KW - Children

KW - Equivocal ultrasound

KW - MRI

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U2 - 10.1016/j.jpedsurg.2018.06.021

DO - 10.1016/j.jpedsurg.2018.06.021

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SP - 1359

EP - 1364

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

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