Abuse of Pentazocine-Naloxone Combination

Deborah A. Reed; Sidney H. Schnoll

doi:10.1001/jama.1986.03380180124033

Abuse of Pentazocine-Naloxone Combination

Deborah A. Reed, Sidney H. Schnoll^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The combination of pentazocine hydrochloride and tripelennamine hydrochloride (T's and blues) has been abused as a heroin substitute. In response to this abuse, the formulation of pentazocine has been changed to include naloxone hydrochloride, a short-acting narcotic antagonist, in the tablet (Talwin Nx). Two cases of abuse of the new pentazocine and naloxone formulation along with tripelennamine are reported. Potential reasons for the failure of naloxone to block the effects of pentazocine are discussed.

Original language	English (US)
Pages (from-to)	2562-2564
Number of pages	3
Journal	JAMA: The Journal of the American Medical Association
Volume	256
Issue number	18
DOIs	https://doi.org/10.1001/jama.1986.03380180124033
State	Published - Nov 14 1986

ASJC Scopus subject areas

General Medicine

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10.1001/jama.1986.03380180124033

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Abuse of Pentazocine-Naloxone Combination

Abstract

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