Abuse of Pentazocine-Naloxone Combination

Deborah A. Reed, Sidney H. Schnoll*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The combination of pentazocine hydrochloride and tripelennamine hydrochloride (T's and blues) has been abused as a heroin substitute. In response to this abuse, the formulation of pentazocine has been changed to include naloxone hydrochloride, a short-acting narcotic antagonist, in the tablet (Talwin Nx). Two cases of abuse of the new pentazocine and naloxone formulation along with tripelennamine are reported. Potential reasons for the failure of naloxone to block the effects of pentazocine are discussed.

Original languageEnglish (US)
Pages (from-to)2562-2564
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Issue number18
StatePublished - Nov 14 1986

ASJC Scopus subject areas

  • Medicine(all)


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