TY - JOUR
T1 - Accelerated biological aging and risk of depression and anxiety
T2 - evidence from 424,299 UK Biobank participants
AU - Gao, Xu
AU - Geng, Tong
AU - Jiang, Meijie
AU - Huang, Ninghao
AU - Zheng, Yinan
AU - Belsky, Daniel W.
AU - Huang, Tao
N1 - Funding Information:
Dr. Tao Huang was supported by the National Natural Science Foundation of China (82173499). Dr. Xu Gao was supported by grants from China CDC Key Laboratory of Environment and Population Health (2022-CKL-03) and Peking University (BMU2021YJ044). Dr. Daniel W. Belsky was supported as a Fellow of the Canadian Institute for Advanced Research CBD Network. We thank Dr. Chen Chen for language assistance.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Theory predicts that biological processes of aging may contribute to poor mental health in late life. To test this hypothesis, we evaluated prospective associations between biological age and incident depression and anxiety in 424,299 UK Biobank participants. We measured biological age from clinical traits using the KDM-BA and PhenoAge algorithms. At baseline, participants who were biologically older more often experienced depression/anxiety. During a median of 8.7 years of follow-up, participants with older biological age were at increased risk of incident depression/anxiety (5.9% increase per standard deviation [SD] of KDM-BA acceleration, 95% confidence intervals [CI]: 3.3%–8.5%; 11.3% increase per SD of PhenoAge acceleration, 95% CI: 9.%–13.0%). Biological-aging-associated risk of depression/anxiety was independent of and additive to genetic risk measured by genome-wide-association-study-based polygenic scores. Advanced biological aging may represent a potential risk factor for incident depression/anxiety in midlife and older adults and a potential target for risk assessment and intervention.
AB - Theory predicts that biological processes of aging may contribute to poor mental health in late life. To test this hypothesis, we evaluated prospective associations between biological age and incident depression and anxiety in 424,299 UK Biobank participants. We measured biological age from clinical traits using the KDM-BA and PhenoAge algorithms. At baseline, participants who were biologically older more often experienced depression/anxiety. During a median of 8.7 years of follow-up, participants with older biological age were at increased risk of incident depression/anxiety (5.9% increase per standard deviation [SD] of KDM-BA acceleration, 95% confidence intervals [CI]: 3.3%–8.5%; 11.3% increase per SD of PhenoAge acceleration, 95% CI: 9.%–13.0%). Biological-aging-associated risk of depression/anxiety was independent of and additive to genetic risk measured by genome-wide-association-study-based polygenic scores. Advanced biological aging may represent a potential risk factor for incident depression/anxiety in midlife and older adults and a potential target for risk assessment and intervention.
UR - http://www.scopus.com/inward/record.url?scp=85153433043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85153433043&partnerID=8YFLogxK
U2 - 10.1038/s41467-023-38013-7
DO - 10.1038/s41467-023-38013-7
M3 - Article
C2 - 37080981
AN - SCOPUS:85153433043
SN - 2041-1723
VL - 14
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 2277
ER -
