Accelerated MR parameter mapping with a union of local subspaces constraint

Sagar Mandava, Mahesh B. Keerthivasan, Zhitao Li, Diego R. Martin, Maria I. Altbach, Ali Bilgin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Purpose: A new reconstruction method for multi-contrast imaging and parameter mapping based on a union of local subspaces constraint is presented. Theory: Subspace constrained reconstructions use a predetermined subspace to explicitly constrain the relaxation signals. The choice of subspace size (K) impacts the approximation error vs noise-amplification tradeoff associated with these methods. A different approach is used in the model consistency constraint (MOCCO) framework to leverage the subspace model to enforce a softer penalty. Our proposed method, MOCCO-LS, augments the MOCCO model with a union of local subspaces (LS) approach. The union of local subspaces model is coupled with spatial support constraints and incorporated into the MOCCO framework to regularize the contrast signals in the scene. Methods: The performance of the MOCCO-LS method was evaluated in vivo on T1 and T2 mapping of the human brain and with Monte-Carlo simulations and compared against MOCCO and the explicit subspace constrained models. Results: The results demonstrate a clear improvement in the multi-contrast images and parameter maps. We sweep across the model order space (Formula presented.) to compare the different reconstructions and demonstrate that the reconstructions have different preferential operating points. Experiments on T2 mapping show that the proposed method yields substantial improvements in performance even when operating at very high acceleration rates. Conclusions: The use of a union of local subspace constraints coupled with a sparsity promoting penalty leads to improved reconstruction quality of multi-contrast images and parameter maps.

Original languageEnglish (US)
Pages (from-to)2744-2758
Number of pages15
JournalMagnetic resonance in medicine
Issue number6
StatePublished - Dec 2018


  • clustering
  • image reconstruction
  • multi-contrast
  • parameter mapping
  • sparsity constraint
  • union of subspaces constraint

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Accelerated MR parameter mapping with a union of local subspaces constraint'. Together they form a unique fingerprint.

Cite this