Accelerated resolution of laser-induced bruising with topical 20% arnica

A rater-blinded randomized controlled trial

S. Leu, J. Havey, L. E. White, N. Martin, Simon S Yoo, Alfred W Rademaker, Murad Alam*

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background Dermatological procedures can result in disfiguring bruises that resolve slowly. Objectives To assess the comparative utility of topical formulations in hastening the resolution of skin bruising. Methods Healthy volunteers, age range 21-65 years, were enrolled for this double (patient and rater) blinded randomized controlled trial. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0·3% retinol, 20% arnica, or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist not involved with subject assignment rated bruises [visual analogue scale, 0 (least)-10 (most)] in standardized photographs immediately after bruise creation and at week 2. Results There was significant difference in the change in the rater bruising score associated with the four treatments (anova, P = 0·016). Pairwise comparisons indicated that the mean improvement associated with 20% arnica was greater than with white petrolatum (P = 0·003), and the improvement with arnica was greater than with the mixture of 1% vitamin K and 0·3% retinol (P = 0·01). Improvement with arnica was not greater than with 5% vitamin K cream, however. Conclusions Topical 20% arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.

Original languageEnglish (US)
Pages (from-to)557-563
Number of pages7
JournalBritish Journal of Dermatology
Volume163
Issue number3
DOIs
StatePublished - Sep 1 2010

Fingerprint

Arnica
Contusions
Vitamin K 1
Lasers
Randomized Controlled Trials
Vitamin K
Vitamin A
Petrolatum
Arm
Dye Lasers
Random Allocation
Ointments
Visual Analog Scale
Healthy Volunteers
Placebos
Skin

Keywords

  • arnica
  • bruise
  • contusions
  • postoperative complications
  • randomized controlled trial
  • vitamin K

ASJC Scopus subject areas

  • Dermatology

Cite this

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title = "Accelerated resolution of laser-induced bruising with topical 20{\%} arnica: A rater-blinded randomized controlled trial",
abstract = "Background Dermatological procedures can result in disfiguring bruises that resolve slowly. Objectives To assess the comparative utility of topical formulations in hastening the resolution of skin bruising. Methods Healthy volunteers, age range 21-65 years, were enrolled for this double (patient and rater) blinded randomized controlled trial. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). Randomization was used to assign one topical agent (5{\%} vitamin K, 1{\%} vitamin K and 0·3{\%} retinol, 20{\%} arnica, or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist not involved with subject assignment rated bruises [visual analogue scale, 0 (least)-10 (most)] in standardized photographs immediately after bruise creation and at week 2. Results There was significant difference in the change in the rater bruising score associated with the four treatments (anova, P = 0·016). Pairwise comparisons indicated that the mean improvement associated with 20{\%} arnica was greater than with white petrolatum (P = 0·003), and the improvement with arnica was greater than with the mixture of 1{\%} vitamin K and 0·3{\%} retinol (P = 0·01). Improvement with arnica was not greater than with 5{\%} vitamin K cream, however. Conclusions Topical 20{\%} arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1{\%} vitamin K with 0·3{\%} retinol.",
keywords = "arnica, bruise, contusions, postoperative complications, randomized controlled trial, vitamin K",
author = "S. Leu and J. Havey and White, {L. E.} and N. Martin and Yoo, {Simon S} and Rademaker, {Alfred W} and Murad Alam",
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Accelerated resolution of laser-induced bruising with topical 20% arnica : A rater-blinded randomized controlled trial. / Leu, S.; Havey, J.; White, L. E.; Martin, N.; Yoo, Simon S; Rademaker, Alfred W; Alam, Murad.

In: British Journal of Dermatology, Vol. 163, No. 3, 01.09.2010, p. 557-563.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Accelerated resolution of laser-induced bruising with topical 20% arnica

T2 - A rater-blinded randomized controlled trial

AU - Leu, S.

AU - Havey, J.

AU - White, L. E.

AU - Martin, N.

AU - Yoo, Simon S

AU - Rademaker, Alfred W

AU - Alam, Murad

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Background Dermatological procedures can result in disfiguring bruises that resolve slowly. Objectives To assess the comparative utility of topical formulations in hastening the resolution of skin bruising. Methods Healthy volunteers, age range 21-65 years, were enrolled for this double (patient and rater) blinded randomized controlled trial. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0·3% retinol, 20% arnica, or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist not involved with subject assignment rated bruises [visual analogue scale, 0 (least)-10 (most)] in standardized photographs immediately after bruise creation and at week 2. Results There was significant difference in the change in the rater bruising score associated with the four treatments (anova, P = 0·016). Pairwise comparisons indicated that the mean improvement associated with 20% arnica was greater than with white petrolatum (P = 0·003), and the improvement with arnica was greater than with the mixture of 1% vitamin K and 0·3% retinol (P = 0·01). Improvement with arnica was not greater than with 5% vitamin K cream, however. Conclusions Topical 20% arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.

AB - Background Dermatological procedures can result in disfiguring bruises that resolve slowly. Objectives To assess the comparative utility of topical formulations in hastening the resolution of skin bruising. Methods Healthy volunteers, age range 21-65 years, were enrolled for this double (patient and rater) blinded randomized controlled trial. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0·3% retinol, 20% arnica, or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist not involved with subject assignment rated bruises [visual analogue scale, 0 (least)-10 (most)] in standardized photographs immediately after bruise creation and at week 2. Results There was significant difference in the change in the rater bruising score associated with the four treatments (anova, P = 0·016). Pairwise comparisons indicated that the mean improvement associated with 20% arnica was greater than with white petrolatum (P = 0·003), and the improvement with arnica was greater than with the mixture of 1% vitamin K and 0·3% retinol (P = 0·01). Improvement with arnica was not greater than with 5% vitamin K cream, however. Conclusions Topical 20% arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.

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KW - randomized controlled trial

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