Access to α-Pyrazole and α-Triazole Derivatives of Ketones from Oxidative Heteroarylation of Silyl Enolethers

Sandeep Dhanju, Aidan C. Caravana, Regan J. Thomson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of α-pyrazole and α-triazole derivatives of ketones by the ceric ammonium nitrate-mediated oxidative coupling of enolsilanes with heteroarenes is reported. The reaction proceeds under mild reaction conditions to provide a diversity of products, including sterically hindered fully substituted derivatives.

Original languageEnglish (US)
Pages (from-to)8055-8058
Number of pages4
JournalOrganic Letters
Volume22
Issue number20
DOIs
StatePublished - Oct 16 2020

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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