TY - JOUR
T1 - Accessory abducens nucleus and conditioned eye retraction/nictitating membrane extension in rabbit
AU - Disterhoft, J. F.
AU - Quinn, K. J.
AU - Weiss, C.
AU - Shipley, M. T.
PY - 1985
Y1 - 1985
N2 - The role of accessory abducens nucleus neurons in the conditioned eye retraction/nictitating membrane extension response was defined in the rabbit. Horseradish peroxidase injections into the retractor bulbi muscle showed that accessory abducens nucleus is the principal location of its motorneurons. Single and multiple unit recording in accessory abducens indicated that these motor neurons show a marked responsiveness to corneal and periorbital stimulation and fire in close correlation with conditioned, unconditioned, or spontaneous eye retraction/nictitating membrane extension. Complete lesions of accessory abducens showed, at most, a partial reduction of the conditioned and unconditioned eye retraction response. Section of the extraocular muscles, other than retractor bulbi, also caused a partial reduction of the eye retraction response. Accessory abducens lesions, combined with extraocular muscle section, were necessary to dramatically reduce the eye retraction response permanently. These experiments demonstrated that accessory abducens is a primary controller of eye retraction through its axons to retractor bulbi. The other extraocular muscles act in concert with retractor bulbi to elicit conditioned and unconditioned eye retractions.
AB - The role of accessory abducens nucleus neurons in the conditioned eye retraction/nictitating membrane extension response was defined in the rabbit. Horseradish peroxidase injections into the retractor bulbi muscle showed that accessory abducens nucleus is the principal location of its motorneurons. Single and multiple unit recording in accessory abducens indicated that these motor neurons show a marked responsiveness to corneal and periorbital stimulation and fire in close correlation with conditioned, unconditioned, or spontaneous eye retraction/nictitating membrane extension. Complete lesions of accessory abducens showed, at most, a partial reduction of the conditioned and unconditioned eye retraction response. Section of the extraocular muscles, other than retractor bulbi, also caused a partial reduction of the eye retraction response. Accessory abducens lesions, combined with extraocular muscle section, were necessary to dramatically reduce the eye retraction response permanently. These experiments demonstrated that accessory abducens is a primary controller of eye retraction through its axons to retractor bulbi. The other extraocular muscles act in concert with retractor bulbi to elicit conditioned and unconditioned eye retractions.
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U2 - 10.1523/jneurosci.05-04-00941.1985
DO - 10.1523/jneurosci.05-04-00941.1985
M3 - Article
C2 - 3981250
AN - SCOPUS:0021979306
SN - 0270-6474
VL - 5
SP - 941
EP - 950
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 4
ER -