Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity

Catalina Lee Chang, Monica Bodogai, Kanako Moritoh, Purevdorj B. Olkhanud, Andrew C. Chan, Michael Croft, Julie A. Mattison, Peter Johannes Holst, Ronald E. Gress, Luigi Ferrucci, Fran Hakim, Arya Biragyn*

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Although the accumulation of highly-differentiated and granzyme B (GrB)-expressing CD8+CD28- T cells has been associated with aging, the mechanism for their enrichment and contribution to immune function remains poorly understood. Here we report a novel B-cell subset expressing 4-1BBL, which increases with age in humans, rhesus macaques, and mice, and with immune reconstitution after chemotherapy and autologous progenitor cell transplantation. These cells (termed 4BL cells) induce GrB +CD8+ T cells by presenting endogenous antigens and using the 4-1BBL/4-1BB axis. We found that the 4BL cells increase antitumor responses in old mice, which may explain in part the paradox of retarded tumor growth in the elderly. 4BL cell accumulation and its capacity to evoke the generation of GrB+CD8+ T cells can be eliminated by inducing reconstitution of B cells in oldmice, suggesting that the age-associated skewed cellular immune responses are reversible. We propose that 4BL cells and the 4-1BBL signaling pathway are useful targets for improved effectiveness of natural antitumor defenses and therapeutic immune manipulations in the elderly.

Original languageEnglish (US)
Pages (from-to)1450-1459
Number of pages10
JournalBlood
Volume124
Issue number9
DOIs
StatePublished - Aug 28 2014

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Lee Chang, C., Bodogai, M., Moritoh, K., Olkhanud, P. B., Chan, A. C., Croft, M., Mattison, J. A., Holst, P. J., Gress, R. E., Ferrucci, L., Hakim, F., & Biragyn, A. (2014). Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity. Blood, 124(9), 1450-1459. https://doi.org/10.1182/blood-2014-03-563940