TY - JOUR
T1 - Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity
AU - Lee Chang, Catalina
AU - Bodogai, Monica
AU - Moritoh, Kanako
AU - Olkhanud, Purevdorj B.
AU - Chan, Andrew C.
AU - Croft, Michael
AU - Mattison, Julie A.
AU - Holst, Peter Johannes
AU - Gress, Ronald E.
AU - Ferrucci, Luigi
AU - Hakim, Fran
AU - Biragyn, Arya
PY - 2014/8/28
Y1 - 2014/8/28
N2 - Although the accumulation of highly-differentiated and granzyme B (GrB)-expressing CD8+CD28- T cells has been associated with aging, the mechanism for their enrichment and contribution to immune function remains poorly understood. Here we report a novel B-cell subset expressing 4-1BBL, which increases with age in humans, rhesus macaques, and mice, and with immune reconstitution after chemotherapy and autologous progenitor cell transplantation. These cells (termed 4BL cells) induce GrB +CD8+ T cells by presenting endogenous antigens and using the 4-1BBL/4-1BB axis. We found that the 4BL cells increase antitumor responses in old mice, which may explain in part the paradox of retarded tumor growth in the elderly. 4BL cell accumulation and its capacity to evoke the generation of GrB+CD8+ T cells can be eliminated by inducing reconstitution of B cells in oldmice, suggesting that the age-associated skewed cellular immune responses are reversible. We propose that 4BL cells and the 4-1BBL signaling pathway are useful targets for improved effectiveness of natural antitumor defenses and therapeutic immune manipulations in the elderly.
AB - Although the accumulation of highly-differentiated and granzyme B (GrB)-expressing CD8+CD28- T cells has been associated with aging, the mechanism for their enrichment and contribution to immune function remains poorly understood. Here we report a novel B-cell subset expressing 4-1BBL, which increases with age in humans, rhesus macaques, and mice, and with immune reconstitution after chemotherapy and autologous progenitor cell transplantation. These cells (termed 4BL cells) induce GrB +CD8+ T cells by presenting endogenous antigens and using the 4-1BBL/4-1BB axis. We found that the 4BL cells increase antitumor responses in old mice, which may explain in part the paradox of retarded tumor growth in the elderly. 4BL cell accumulation and its capacity to evoke the generation of GrB+CD8+ T cells can be eliminated by inducing reconstitution of B cells in oldmice, suggesting that the age-associated skewed cellular immune responses are reversible. We propose that 4BL cells and the 4-1BBL signaling pathway are useful targets for improved effectiveness of natural antitumor defenses and therapeutic immune manipulations in the elderly.
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U2 - 10.1182/blood-2014-03-563940
DO - 10.1182/blood-2014-03-563940
M3 - Article
C2 - 25037628
AN - SCOPUS:84907320066
SN - 0006-4971
VL - 124
SP - 1450
EP - 1459
JO - Blood
JF - Blood
IS - 9
ER -