Accumulation of indium-111-labeled human low density lipoprotein in the rabbit aorta: Implications for nuclear imaging of vascular lesions

Rick V. Hay*, David D. Casalino, Leszek Kordylewski, Robert W. Atcher, Martin W. Brechbiel, Otto A. Gansow, Ute Sharokhizadeh, Richard M. Fleming, Katherine A. Lathrop, Violet J. Stark, Paul V. Harper

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Nuclear imaging of atheromata must distinguish lesions from both blood pool and normal arterial tissue. We have examined spatial and temporal variations of indium-111-labeled human low density lipoprotein (LDL) accumulation in rabbit aortas. LDL-derived In-111 activity was time-independent in lesion-resistant regions of aortas from normal and hypercholesterolemic animals (mean 2.9 × 10-6 percent injected activity per milligram tissue [%IA/mg]) and in lesion-prone regions of normal aortas (mean 7.1 × 10-6 %IA/mg). In contrast, activity in sudanophilic lesions of hypercholesterolemic rabbit aortas reached a peak of 31 × 10-6 %IA/mg at 92 hours postinjection. The mean ratio between activity in lesions versus lesion-resistant regions described a broad convex curve with minima of 4:1 at 14 hours and 136 hours and a peak of 14:1 measured at 72 hours postinjection. The mean ratio between In-111 in lesions and blood followed a sigmoid curve, rising exponentially from 1:25 at 14 hours to 1:3 by 72 hours postinjection. We conclude that optimal signal-to-noise ratios for monitoring atheroma-associated LDL-derived radioactivity occur late, not before about 3 days postinjection. Therefore, LDL labeled with In-111 or even longer-lived radionuclides holds the greatest promise for effective clinical nuclear imaging of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)189-198
Number of pages10
JournalCardiovascular Pathology
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cardiology and Cardiovascular Medicine

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    Hay, R. V., Casalino, D. D., Kordylewski, L., Atcher, R. W., Brechbiel, M. W., Gansow, O. A., Sharokhizadeh, U., Fleming, R. M., Lathrop, K. A., Stark, V. J., & Harper, P. V. (1992). Accumulation of indium-111-labeled human low density lipoprotein in the rabbit aorta: Implications for nuclear imaging of vascular lesions. Cardiovascular Pathology, 1(3), 189-198. https://doi.org/10.1016/1054-8807(92)90024-I