Accuracy of individual trabecula segmentation based plate and rod finite element models in idealized trabecular bone microstructure

Hong Wang, X. Sherry Liu, Bin Zhou, Ji Wang, Baohua Ji, Yonggang Huang, Keh Chih Hwang, X. Edward Guo*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Currently, specimen-specific micro finite element (μFE) analysis based micro computed tomography (μCT) images have become a major computational tool for the assessment of the mechanical properties of human trabecular bone. Despite the fine characterization of the three-dimensional (3D) trabecular microstructure based on high-resolution μCT images, conventional μFE models with each voxel converted to an element are not efficient in predicting the nonlinear failure behavior of bone due to a prohibitive computational cost. Recently, a highly efficient individual trabecula segmentation (ITS)-based plate and rod (PR) modeling technique has been developed by substituting individual plates and rods with shell and beam elements, respectively. In this technical brief, the accuracy of novel PR μFE models was examined in idealized microstructure models over a broad range of trabecular thicknesses. The Young's modulus and yield strength predicted by simplified PR models strongly correlated with those of voxel models at various voxel sizes. The conversion from voxel models to PR models resulted in an ∼762-fold reduction in the largest model size and significantly accelerated the nonlinear FE analysis. The excellent predictive power of the PR μFE models, demonstrated in an idealized trabecular microstructure, provided a quantitative mechanical basis for this promising tool for an accurate and efficient assessment of trabecular bone mechanics and fracture risk.

Original languageEnglish (US)
Article number44502
JournalJournal of Biomechanical Engineering
Volume135
Issue number4
DOIs
StatePublished - May 15 2013

Fingerprint

Finite Element Analysis
Bone
Tomography
Microstructure
Elastic Modulus
Bone Fractures
Mechanics
Costs and Cost Analysis
Bone and Bones
Cancellous Bone
Finite element method
Yield stress
Elastic moduli
Mechanical properties

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

Cite this

Wang, Hong ; Sherry Liu, X. ; Zhou, Bin ; Wang, Ji ; Ji, Baohua ; Huang, Yonggang ; Hwang, Keh Chih ; Edward Guo, X. / Accuracy of individual trabecula segmentation based plate and rod finite element models in idealized trabecular bone microstructure. In: Journal of Biomechanical Engineering. 2013 ; Vol. 135, No. 4.
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abstract = "Currently, specimen-specific micro finite element (μFE) analysis based micro computed tomography (μCT) images have become a major computational tool for the assessment of the mechanical properties of human trabecular bone. Despite the fine characterization of the three-dimensional (3D) trabecular microstructure based on high-resolution μCT images, conventional μFE models with each voxel converted to an element are not efficient in predicting the nonlinear failure behavior of bone due to a prohibitive computational cost. Recently, a highly efficient individual trabecula segmentation (ITS)-based plate and rod (PR) modeling technique has been developed by substituting individual plates and rods with shell and beam elements, respectively. In this technical brief, the accuracy of novel PR μFE models was examined in idealized microstructure models over a broad range of trabecular thicknesses. The Young's modulus and yield strength predicted by simplified PR models strongly correlated with those of voxel models at various voxel sizes. The conversion from voxel models to PR models resulted in an ∼762-fold reduction in the largest model size and significantly accelerated the nonlinear FE analysis. The excellent predictive power of the PR μFE models, demonstrated in an idealized trabecular microstructure, provided a quantitative mechanical basis for this promising tool for an accurate and efficient assessment of trabecular bone mechanics and fracture risk.",
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Accuracy of individual trabecula segmentation based plate and rod finite element models in idealized trabecular bone microstructure. / Wang, Hong; Sherry Liu, X.; Zhou, Bin; Wang, Ji; Ji, Baohua; Huang, Yonggang; Hwang, Keh Chih; Edward Guo, X.

In: Journal of Biomechanical Engineering, Vol. 135, No. 4, 44502, 15.05.2013.

Research output: Contribution to journalArticle

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