Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors

Gloria S. Huang*, Juliana S. Gebb, Mark H. Einstein, Shohreh Shahabi, Akiva P. Novetsky, Gary L. Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Objective: This study was undertaken to evaluate the ability of preoperative endometrial sampling to accurately diagnose high-grade endometrial tumors. Study design: Three hundred sixty endometrial cancer patients had preoperative endometrial sampling and hysterectomy specimens that underwent pathologic review at a single institution from 1995 to 2005. The sensitivity of Pipelle and curettage to diagnose high-grade endometrial tumors (grade 3 endometrioid adenocarcinoma, serous carcinoma, carcinosarcoma, clear cell carcinoma) was determined. Agreement between preoperative and hysterectomy diagnoses was measured by the Kappa statistic. Results: Sensitivity of Pipelle and curettage was 93.8% and 97% in patients with low-grade cancer and 99.2% and 100% in patients with high-grade cancer. Good agreement was observed between the preoperative and the hysterectomy histologic diagnoses (Kappa = 0.69), and between the preoperative and hysterectomy tumor grade (Kappa=0.78). Conclusion: Preoperative endometrial sampling with Pipelle or curettage is sensitive and accurate for the diagnosis of high-grade endometrial tumors, including tumors with nonendometrioid histology.

Original languageEnglish (US)
Pages (from-to)243.e1-243.e5
JournalAmerican journal of obstetrics and gynecology
Issue number3
StatePublished - Mar 2007


  • endometrial biopsy
  • endometrial carcinoma
  • predictive testing

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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