Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm

for the ELGAN Study Investigators

doi:10.1038/s41372-017-0020-8

Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm

for the ELGAN Study Investigators

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Objective: To describe the accuracy of the Bayley Scales of Infant Development-Second Edition (BSID-II) Mental Development Index (MDI) at 2 years of age for prediction of cognitive function at school age of children born extremely preterm. Design: Study participants were enrolled in the Extremely Low Gestational Age Newborn Study between 2002 and 2004. Two-thirds of surviving children (n = 795) were assessed at 2 years with the BSID-II and at 10 years with an intelligence quotient (IQ) test. We computed test characteristics for a low MDI (<70), including predictive value positive. Results: Almost two-thirds of children with a low MDI had a normal IQ (≥ 70) at 10 years. Concordance between MDI and IQ was highest among children with major motor and/or sensory impairment, and when MDI was adjusted for gestational age. Conclusion: Most children born extremely preterm with low BSID-II MDI at 2 years have normal intelligence at school age.

Original language	English (US)
Pages (from-to)	908-916
Number of pages	9
Journal	Journal of Perinatology
Volume	38
Issue number	7
DOIs	https://doi.org/10.1038/s41372-017-0020-8
State	Published - Jul 1 2018

Funding

Acknowledgements This study was supported by the National Institute of Neurological Disorders and Stroke (Grant Nos. 5U01NS040069-05 and 2R01NS040069-09) and the Office of the Director of the National Institutes of Health (1UG3OD023348-01). We also gratefully acknowledge the contributions of their subjects, and their subjects’ families, as well as those of their colleagues listed below. This study was supported by from the Office of the Director, National Institutes of Health (1UG3OD023348-01), the National Institute of Neurological Disorders and Stroke (5U01NS040069-05 and 2R01NS040069-09), and the National Institute of Child Health and Human Development (5P30HD018655-28). Dr. Frazier has the following disclosures: serving on the data safety monitoring board for Forest Pharmaceuticals and receiving research support from Alcobra, Janssen Pharmaceuticals, Neuren, and SyneuRX International.

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/s41372-017-0020-8

Cite this

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title = "Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm",

abstract = "Objective: To describe the accuracy of the Bayley Scales of Infant Development-Second Edition (BSID-II) Mental Development Index (MDI) at 2 years of age for prediction of cognitive function at school age of children born extremely preterm. Design: Study participants were enrolled in the Extremely Low Gestational Age Newborn Study between 2002 and 2004. Two-thirds of surviving children (n = 795) were assessed at 2 years with the BSID-II and at 10 years with an intelligence quotient (IQ) test. We computed test characteristics for a low MDI (<70), including predictive value positive. Results: Almost two-thirds of children with a low MDI had a normal IQ (≥ 70) at 10 years. Concordance between MDI and IQ was highest among children with major motor and/or sensory impairment, and when MDI was adjusted for gestational age. Conclusion: Most children born extremely preterm with low BSID-II MDI at 2 years have normal intelligence at school age.",

author = "{for the ELGAN Study Investigators} and O{\textquoteright}Shea, {Thomas M.} and Joseph, {Robert M.} and Allred, {Elizabeth N.} and Taylor, {H. Gerry} and Alan Leviton and Tim Heeren and Douglass, {Laurie M.} and Frazier, {Jean A.} and Hernan Jara and Kuban, {Karl C.K.} and Bhahvesh Shah and Rachana Singh and {Van Marter}, Linda and Camilla Martin and Janice Ware and Cynthia Cole and Ellen Perrin and Frank Bednarek and Richard Ehrenkranz and Jennifer Benjamin and Carl Bose and Diane Warner and Steve Engelke and Mariel Poortenga and Steve Pastyrnak and Padu Karna and Nigel Paneth and Madeleine Lenski and Michael Schreiber and Scott Hunter and Michael Msall and Danny Batton and Judith Klarr and Karen Christianson and Deborah Klein and Maureen Pimental and Collen Hallisey and Taryn Coster and Ellen Nylen and Emily Neger and Kathryn Mattern and Lauren Venuti and Beth Powers and Ann Foley and Joanne Williams and Elaine Romano and Debbie Hiatt and Nancy Peters and Patricia Brown and Megan Scott",

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AU - Allred, Elizabeth N.

AU - Taylor, H. Gerry

AU - Leviton, Alan

AU - Heeren, Tim

AU - Douglass, Laurie M.

AU - Frazier, Jean A.

AU - Jara, Hernan

AU - Kuban, Karl C.K.

AU - Shah, Bhahvesh

AU - Singh, Rachana

AU - Van Marter, Linda

AU - Martin, Camilla

AU - Ware, Janice

AU - Cole, Cynthia

AU - Perrin, Ellen

AU - Bednarek, Frank

AU - Ehrenkranz, Richard

AU - Benjamin, Jennifer

AU - Bose, Carl

AU - Warner, Diane

AU - Engelke, Steve

AU - Poortenga, Mariel

AU - Pastyrnak, Steve

AU - Karna, Padu

AU - Paneth, Nigel

AU - Lenski, Madeleine

AU - Schreiber, Michael

AU - Hunter, Scott

AU - Msall, Michael

AU - Batton, Danny

AU - Klarr, Judith

AU - Christianson, Karen

AU - Klein, Deborah

AU - Pimental, Maureen

AU - Hallisey, Collen

AU - Coster, Taryn

AU - Nylen, Ellen

AU - Neger, Emily

AU - Mattern, Kathryn

AU - Venuti, Lauren

AU - Powers, Beth

AU - Foley, Ann

AU - Williams, Joanne

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AU - Hiatt, Debbie

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AU - Brown, Patricia

AU - Scott, Megan

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N2 - Objective: To describe the accuracy of the Bayley Scales of Infant Development-Second Edition (BSID-II) Mental Development Index (MDI) at 2 years of age for prediction of cognitive function at school age of children born extremely preterm. Design: Study participants were enrolled in the Extremely Low Gestational Age Newborn Study between 2002 and 2004. Two-thirds of surviving children (n = 795) were assessed at 2 years with the BSID-II and at 10 years with an intelligence quotient (IQ) test. We computed test characteristics for a low MDI (<70), including predictive value positive. Results: Almost two-thirds of children with a low MDI had a normal IQ (≥ 70) at 10 years. Concordance between MDI and IQ was highest among children with major motor and/or sensory impairment, and when MDI was adjusted for gestational age. Conclusion: Most children born extremely preterm with low BSID-II MDI at 2 years have normal intelligence at school age.

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Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm

Abstract

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