ACE2 alterations in kidney disease

María José Soler*, Jan Wysocki, Daniel Batlle

*Corresponding author for this work

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that degrades angiotensin (Ang) II to Ang-(1-7). ACE2 is highly expressed within the kidneys, it is largely localized in tubular epithelial cells and less prominently in glomerular epithelial cells and in the renal vasculature. ACE2 activity has been shown to be altered in diabetic kidney disease, hypertensive renal disease and in different models of kidney injury. There is often a dissociation between tubular and glomerular ACE2 expression, particularly in diabetic kidney disease where ACE2 expression is increased at the tubular level but decreased at the glomerular level. In this review, we will discuss alterations in circulating and renal ACE2 recently described in different renal pathologies and disease models as well as their possible significance.

Original languageEnglish (US)
Pages (from-to)2687-2697
Number of pages11
JournalNephrology Dialysis Transplantation
Volume28
Issue number11
DOIs
StatePublished - Nov 1 2013

Keywords

  • ACE2
  • Kidney disease
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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